| mir-598 | |
|---|---|
| Identifiers | |
| Symbol | mir-598 |
| Rfam | RF01059 |
| miRBase family | MIPF0000393 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-598 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-598 has been shown to directly target and inhibit the Sir2 homolog, silent information regulator one (SRT1) enzyme, in the senescence of human adipose-tissue-derived mesenchymal stem cells. Increased miR-598 expression during the senescent state is accompanied by a decreased expression of SRT1, meaning an absence of the inhibited p53 acetylation usually observed with increased STR1 levels.[1] miR-598 acts to modulate cellular senescence. More specifically, its overexpression induces senescence in early-passage cells whilst inhibition conversely sees a partial recovery of the ageing phenotype through increased cellular differentiation.