Route 15
Route information
Maintained by MoDOT
Length	118 mi (190 km)
Existed	1922–present
Major junctions
South end	US 54 / US 54 Bus. in Mexico
Major intersections	US 24 near Paris US 36 / Route 110 (CKC) in Shelbina US 136 / US 136 Bus. in Memphis
North end	CR V56 near Milton, Iowa[1]
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 14 → Route 16

Route 15 is a highway in northeast Missouri. Its northern terminus is at the Iowa state line about thirteen miles (19 km) north of Memphis; its southern terminus is at U.S. Route 54 in Mexico.

Route 15 is one of the original 1922 Missouri highways, though its southern terminus was significantly farther at Route 71 (now U.S. Route 65) at Buffalo. It was replaced by U.S. Route 54 from Mexico to southwest of Macks Creek and by Route 73 from that point to Buffalo.

Major intersections

County	Location	mi	km	Destinations	Notes
Audrain	Mexico			US 54 / Route D / US 54 Bus. – Bowling Green, Jefferson City, Auxvasse	interchange; southern end of US 54 Bus. / Route 22 overlap
				US 54 Bus. east (Boulevard Street) / S. Clark Street	northern end of US 54 Bus. overlap
				Route 22 (Monroe Street) – Centralia	northern end of Route 22 overlap
Monroe	​			Route 154 – Perry	southern end of Route 154 overlap
	Paris			US 24 Bus. / Route 154 – Madison	northern end of Route 154 overlap; southern end of US 24 Bus. overlap
	​			US 24 / US 24 Bus. – Madison, Monroe City, Paris	northern end of US 24 Bus. overlap
Shelby	Shelbina			US 36 Bus. (Maple Street)
				US 36 / Route 110 (CKC) – Macon, Monroe City	interchange
	Shelbyville			Route 168 (Main Street) / Route K – Hagers Grove, Emden
Knox	​			Route 156 – Newark	southern end of Route 156 overlap; access to Henry Sever Lake Conservation Area
	​			Route 156 / Route 151 – Novelty	northern end of Route 156 overlap
	​			Route 6 – Kirksville	southern end of Route 6 overlap
	Edina			Route 6 – Knox City	northern end of Route 6 overlap
	​			Route 11 south / Route K east – Adair, Baring
Scotland	​			US 136 west – Lancaster	southern end of US 136 overlap
	Memphis			US 136 east – Kahoka	northern end of US 136 overlap; southern end of US 136 Bus. overlap
				US 136 Bus. east (Monroe Street)	northern end of US 136 Bus. overlap
	​			CR V56 north – Milton	former Iowa 15
1.000 mi = 1.609 km; 1.000 km = 0.621 mi