Route 151
MO 151 highlighted in red
Route information
Maintained by MoDOT
Length	68.569 mi[1] (110.351 km)
Major junctions
South end	Route 22 / Route 124 in Centralia
Major intersections	US 24 in Madison US 36 / Route 110 (CKC) in Clarence
North end	Route 15 / Route 156 south of Edina
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 150 → Route 152

Route 151 is a highway in the U.S. state of Missouri. Its northern terminus is at Route 15/Route 156 about 13 miles (21 km) south of Edina; its southern terminus is at Route 22/Route 124 in Centralia.

Route 151 was designated in 1949, replacing all or part of several state-lettered routes. In 1955, Route 151 was extended onto an old alignment of Route 22 after Route 22 was realigned west of Centralia. Because of the extension, Route 151 intersects Route 22 twice and the two routes are briefly multiplexed.^[2] As of 1957, Route 151 was completely hard-surfaced.^[3]

Major intersections

County	Location	mi[1]	km	Destinations	Notes
Boone	Centralia	0.000	0.000	Route 22 / Route 124 south – Hallsville, Mexico
Boone–Audrain county line	Bourbon–Saling township line	5.802	9.337	Route 22 east – Centralia	Southern end of Route 22 overlap
Audrain	Saling Township	6.113	9.838	Route 22 west to US 63	Northern end of Route 22 overlap
Monroe	Madison	22.776	36.654	US 24 west – Moberly	Southern end of US 24 overlap
		22.903	36.859	US 24 east – Paris	Northern end of US 24 overlap
Shelby	Clarence	45.032	72.472	US 36 Bus. to US 36 – Macon, Shelbina	Access to eastbound US 36 / Route 110
		45.274	72.861	US 36 west / Route 110 (CKC) west – Macon	No access to or from eastbound US 36 / Route 110
Knox	Salt River–Bourbon township line	68.185	109.733	Route 156 west – Novelty	Southern end of Route 156 overlap
	Bourbon Township	68.569	110.351	Route 15 / Route 156 east – Plevna, Edina	Northern end of Route 156 overlap
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access