Route 6
Route information
Maintained by MoDOT
Length	211 mi (340 km)
Existed	1922–present
Major junctions
West end	I-29 BL / US 169 in St. Joseph
Major intersections	I-29 in St. Joseph I-35 north of Winston US 69 west of Altamont US 65 in Trenton US 63 / Route 11 in Kirksville
East end	US 24 / US 61 south of Taylor
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 5 → Route 7

Route 6 is a 211-mile-long (340 km) state highway in the northern part of the U.S. state of Missouri. It travels from I-29 Bus./US 169 in St. Joseph to US 24/US 61 about 6 miles (9.7 km) west of Quincy, Illinois. Route 6, if only a few miles longer in each direction, would be the only state highway to cross Missouri west to east. It is one of the original 1922 highways in Missouri.

Route description

Major intersections

County	Location	mi[1]	km	Destinations	Notes
Buchanan	St. Joseph	0.0	0.0	I-29 BL / US 169 (Belt Highway / Frederick Boulevard)
		0.5	0.80	I-29 / US 71 – Council Bluffs, Kansas City	I-29 exit 47
DeKalb	​	13.0	20.9	Route 31 south to US 36	west end of Route 31 overlap
	Oak	22.9	36.9	Route 31 north – King City	east end of Route 31 overlap
	Maysville	32.0	51.5	Route 33 south / Route A north
Daviess	​	43.7	70.3	I-35 – Bethany, Des Moines, Cameron, Kansas City	I-35 exit 64
	​	45.7	73.5	US 69 north – Pattonsburg	west end of US 69 overlap
	​	46.8	75.3	US 69 south – Winston	east end of US 69 overlap
	Gallatin	55.3	89.0	Route 13 south – Hamilton	west end of Route 13 overlap
	​	56.9	91.6	Route 13 north – Jameson	east end of Route 13 overlap
	​	66.0	106.2	Route 190 – Edinburg, Jamesport
Grundy	​	75.0	120.7	Route 146 west / Route W south – Edinburg, Hickory, Crowder State Park
	Trenton	78.9	127.0	US 65 Bus. north (Oklahoma Avenue)	west end of US 65 Bus. overlap
		79.0	127.1	US 65 – Princeton, Chillicothe	interchange; east end of US 65 Bus. overlap
	​	92.4	148.7	Route 139 north – Osgood	west end of Route 139 overlap
Sullivan	Humphreys	95.2	153.2	Route 139 south – Meadville	east end of Route 139 overlap
	​	104.4	168.0	Route 5 south – Linneus	west end of Route 5 overlap
	​	107.6	173.2	Route 5 Bus. north – Milan
	Milan	110.3	177.5	Route 5 Bus. south
		110.5	177.8	Route 5 north – Unionville	east end of Route 5 overlap
	Green City	119.7	192.6	Route 129 – Green City, Winigan
Adair	​	127.7	205.5	Route 149 south to Route 11	west end of Route 149 overlap
	Novinger	133.7	215.2	Route 149 north – Connelsville	east end of Route 149 overlap
	​	137.5	221.3	Route 157 south – Thousand Hills State Park
	Kirksville	140.8	226.6	US 63 Bus. north – Lancaster	west end of US 63 Bus. overlap
		142.4	229.2	US 63 Bus. – Macon	east end of US 63 Bus. overlap
		143.4	230.8	US 63 north / Route 11 north – Lancaster, Adair	west end of US 63/MO 11 overlap
		145.4	234.0	US 63 south / Route 11 south – Macon, Kirksville	east end of US 63/MO 11 overlap
Knox	​	166.5	268.0	Route 15 south – Plevna	west end of Route 15 overlap
	Edina	167.4	269.4	Route 15 north – Memphis	east end of Route 15 overlap
Lewis	​	188.5	303.4	Route 16 east – Monticello
	Ewing	195.5	314.6	Route 156 west – Newark, Henry Sever Lake Conservation Area
	​			Outer Road - Taylor
Marion	​	211	340	US 24 / US 61 (Avenue of the Saints) – Canton, Quincy, IL, Palmyra, Hannibal	interchange
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus