FTMT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R03
Identifiers
Aliases	FTMT, MTF, Mitochondrial ferritin, ferritin mitochondrial
External IDs	OMIM: 608847 MGI: 1914884 HomoloGene: 110661 GeneCards: FTMT
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.1 Start 121,851,882 bp[1] End 121,852,833 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D1 Start 52,464,621 bp[2] End 52,466,068 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human musculoskeletal system muscle of leg gastrocnemius muscle subcutaneous adipose tissue zone of skin prostate tibial nerve Top expressed in seminiferous tubule spermatid spermatocyte pancreas islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function ferric iron binding metal ion binding oxidoreductase activity iron ion binding ferroxidase activity ferrous iron binding identical protein binding Cellular component nucleus mitochondrion mitochondrial matrix cytoplasm Biological process iron ion transport positive regulation of succinate dehydrogenase activity positive regulation of aconitate hydratase activity positive regulation of cell population proliferation positive regulation of lyase activity intracellular sequestering of iron ion cellular iron ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94033 67634 Ensembl ENSG00000181867 ENSMUSG00000024510 UniProt Q8N4E7 Q9D5H4 RefSeq (mRNA) NM_177478 NM_026286 RefSeq (protein) NP_803431 NP_080562 Location (UCSC) Chr 5: 121.85 – 121.85 Mb Chr 18: 52.46 – 52.47 Mb PubMed search [3] [4]
Wikidata
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Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene.^[5]

It is classified as a metal-binding protein which is located within the mitochondria. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin shells.

Structure

Its structure was determined at 1.70 Å through the use of X-ray diffraction and contains 182 residues. It is 67% helical. The Ramachandran plot shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.