MRPL22
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y
Identifiers
Aliases	MRPL22, L22mt, MRP-L22, MRP-L25, RPML25, HSPC158, mitochondrial ribosomal protein L22
External IDs	OMIM: 611835 MGI: 1333794 HomoloGene: 56664 GeneCards: MRPL22
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.2 Start 154,941,073 bp[1] End 154,969,411 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,062,487 bp[2] End 58,070,391 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle islet of Langerhans right ventricle right adrenal gland left adrenal gland body of pancreas right lobe of liver anterior pituitary rectum stromal cell of endometrium Top expressed in morula proximal tubule adrenal gland blastocyst neural tube quadriceps femoris muscle yolk sac heart stomach skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane large ribosomal subunit ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis ribosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29093 216767 Ensembl ENSG00000082515 ENSMUSG00000020514 UniProt Q9NWU5 Q8BU88 RefSeq (mRNA) NM_014180 NM_001014990 NM_175001 RefSeq (protein) NP_001014990 NP_054899 NP_778166 NP_001390902 Location (UCSC) Chr 5: 154.94 – 154.97 Mb Chr 11: 58.06 – 58.07 Mb PubMed search [3] [4]
Wikidata
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39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.^[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.^[5]