MRPL39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL39, C21orf92, L39mt, MRP-L5, MRPL5, PRED22, PRED66, RPML5, MSTP003, mitochondrial ribosomal protein L39, L5mt
External IDs	OMIM: 611845 MGI: 1351620 HomoloGene: 9679 GeneCards: MRPL39
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 25,585,656 bp[1] End 25,607,517 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 84,514,464 bp[2] End 84,532,630 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte left ventricle right adrenal gland Achilles tendon gastrocnemius muscle secondary oocyte left adrenal gland rectum vastus lateralis muscle right ventricle Top expressed in fossa condyle seminiferous tubule facial motor nucleus motor neuron right ventricle primitive streak Paneth cell medial ganglionic eminence hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54148 27393 Ensembl ENSG00000154719 ENSMUSG00000022889 UniProt Q9NYK5 Q9JKF7 RefSeq (mRNA) NM_017446 NM_080794 NM_017404 NM_001384093 NM_001384095 NM_001384096 RefSeq (protein) NP_059142 NP_542984 NP_059100 NP_001371022 NP_001371024 NP_001371025 Location (UCSC) Chr 21: 25.59 – 25.61 Mb Chr 16: 84.51 – 84.53 Mb PubMed search [3] [4]
Wikidata
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39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.^[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.^[6]