Mr. Perfect may refer to:

• Curt Hennig (1958–2003), American wrestler who used the name "Mr. Perfect" in the ring
• Jerry Stubbs (born 1952), American wrestler who used the name "Mr. Perfect" in the ring
• Ernesto Hoost (born 1965), Dutch kickboxer who used the name "Mr. Perfect" in the ring
• Mr. Perfect (film), a 2011 Indian romantic comedy film by Dasaradh, starring Prabhas in the title role
  • Prabhas (born 1979), Indian actor, sometimes nicknamed Mr. Perfect
• "Mr. Perfect" (song), a 2011 song by Greek-Swedish singer Elena Paparizou
• "Mr. Perfect", a song from the 2009 Indian film Arya 2
• "Mr. Perfect", a song from the 2017 Indian film Raajakumara
• Mr. Perfect (Mr. Men), a character from the Mr. Men book and animation series