Mr. Skygack, from Mars was a comic strip by the American cartoonist A. D. Condo. It appeared in the Chicago Day Book, a Chicago working-class newspaper, from October 2, 1907, to April 1911^[1] in about 400 comic strips and single panels.^[2] Like much of Condo's work in this period, the Mr. Skygack feature was syndicated and appeared in many other papers, including The Seattle Star,^[3] The Milwaukee Journal, The Spokane Press, The Pittsburgh Press, The Tacoma Times and The Duluth Daily Star.

The comic followed the titular Mr. Skygack, a Martian, on his mission to study humans. Mr. Skygack's comical misunderstandings of Earthly affairs gave Condo the opportunity to comment on and criticize social norms.^[2][4] Skygack subsequently appeared in Condo's ethnic-humor comic strip Osgar und Adolf.^[5]

Mr. Skygack, from Mars is considered the first science fiction comic,^[6] featuring the first extraterrestrial character in comics history. It also gave rise to the first recorded sci-fi cosplay when a Mr. William Fell was reported wearing a Mr. Skygack costume to a 1908 masquerade.^[2]