This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) The topic of this article may not meet Wikipedia's general notability guideline. Please help to demonstrate the notability of the topic by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be shown, the article is likely to be merged, redirected, or deleted.Find sources: "Multiple sclerosis functional composite" – news · newspapers · books · scholar · JSTOR (July 2013) (Learn how and when to remove this template message) This article relies largely or entirely on a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources.Find sources: "Multiple sclerosis functional composite" – news · newspapers · books · scholar · JSTOR (July 2013) This article relies excessively on references to primary sources. Please improve this article by adding secondary or tertiary sources. Find sources: "Multiple sclerosis functional composite" – news · newspapers · books · scholar · JSTOR (July 2013) (Learn how and when to remove this template message) (Learn how and when to remove this template message)

The Multiple Sclerosis Functional Composite (MSFC) is a clinical trial outcome measure of assessing the severity of multiple sclerosis primarily used in research.[1] The score is based on a combination of timed tests of walking, arm function, and cognitive ability.[1] It was developed over two years from 1994 to 1996 by the National Multiple Sclerosis Society.[1][2]

MSFC was developed to improve the standard measure of MS disability for clinical trials and to create a multidimensional metric of overall MS clinical status. The evaluation includes a three-part performance scale:

An integrated MSFC score is calculated using z-scores.[3]

References

  1. ^ a b c Rudick RA, Cutter G, Reingold S (October 2002). "The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials". Multiple Sclerosis. 8 (5): 359–65. doi:10.1191/1352458502ms845oa. PMID 12356200. S2CID 31529508.
  2. ^ Balcer LJ, Baier ML, Cohen JA, Kooijmans MF, Sandrock AW, Nano-Schiavi ML, et al. (November 2003). "Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite". Neurology. 61 (10): 1367–73. doi:10.1212/01.WNL.0000094315.19931.90. PMID 14638957. S2CID 17583827.
  3. ^ Meyer-Moock S, Feng YS, Maeurer M, Dippel FW, Kohlmann T (March 2014). "Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis". BMC Neurology. 14 (1): 58. doi:10.1186/1471-2377-14-58. PMC 3986942. PMID 24666846.
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