Names | |
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IUPAC name
N6-(Carboxymethyl)-L-lysine
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Systematic IUPAC name
(2S)-2-Amino-6-[(carboxymethyl)amino]hexanoic acid | |
Identifiers | |
3D model (JSmol)
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4989963 S | |
ChEBI | |
ChemSpider | |
MeSH | N(6)-carboxymethyllysine |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C8H16N2O4 | |
Molar mass | 204.226 g·mol−1 |
Related compounds | |
Related alkanoic acids
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gamma-Glutamylcysteine |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N(6)-Carboxymethyllysine (CML), also known as Nε-(carboxymethyl)lysine, is an advanced glycation endproduct (AGE). CML has been the most used marker for AGEs in food analysis.[1]
Recently, it has been demonstrated that gut microbiota mediates an aging-associated decline in gut barrier function, allowing AGEs to leak into the bloodstream from the gut and impairing microglial function in the brain. It is suggested that the amount of CML in human blood samples may correlated with age.[2]
A humanized monoclonal antibody which binds to N6 – carboxymethyl lysine shows considerable promise as a possible therapeutic agent for treating pancreatic cancer.[3]