NAIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VM5
Identifiers
Aliases	NAIP, BIRC1, NLRB1, psiNLR family, apoptosis inhibitory protein, NLR family apoptosis inhibitory protein
External IDs	OMIM: 600355 MGI: 1298226 HomoloGene: 136092 GeneCards: NAIP
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 70,968,166 bp[1] End 71,025,339 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 53.01 cM Start 100,280,571 bp[2] End 100,338,600 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen appendix bone marrow cells right uterine tube ganglionic eminence right lung blood upper lobe of left lung left lobe of thyroid gland Top expressed in left colon ileum Paneth cell jejunum intestinal villus duodenum urethra male urethra parotid gland pyloric antrum More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity nucleotide binding cysteine-type endopeptidase inhibitor activity metal ion binding ubiquitin-protein transferase activity protein binding ATP binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process Cellular component perikaryon neuronal cell body basolateral plasma membrane neuron projection cytoplasm nucleus Biological process negative regulation of neuron apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to amino acid negative regulation of peptidase activity immune system process nervous system development response to axon injury innate immune response inflammatory response apoptotic process protein ubiquitination positive regulation of canonical Wnt signaling pathway mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4671 17948 Ensembl ENSG00000278613 ENSG00000276068 ENSG00000249437 ENSMUSG00000078945 UniProt Q13075 Q9QUK4 RefSeq (mRNA) NM_004536 NM_022892 NM_001346870 NM_001126182 NM_010872 RefSeq (protein) NP_001333799 NP_004527 NP_075043 NP_001119654 NP_035002 Location (UCSC) Chr 5: 70.97 – 71.03 Mb Chr 13: 100.28 – 100.34 Mb PubMed search [3] [4]
Wikidata
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Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.^[5][6]

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]