NDN
Identifiers
AliasesNDN, HsT16328, PWCR, necdin, MAGE family member
External IDsOMIM: 602117 MGI: 97290 HomoloGene: 20559 GeneCards: NDN
Orthologs
SpeciesHumanMouse
Entrez

4692

17984

Ensembl

ENSG00000182636
ENSG00000288364

ENSMUSG00000033585

UniProt

Q99608

P25233

RefSeq (mRNA)

NM_002487

NM_010882

RefSeq (protein)

NP_002478

NP_035012

Location (UCSC)Chr 15: 23.69 – 23.69 MbChr 7: 62 – 62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Necdin is a protein that in humans is encoded by the NDN gene.[5][6]

Function

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.[6]

Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation.[7]

Interactions

NDN (gene) has been shown to interact with:

References

  1. ^ a b c ENSG00000288364 GRCh38: Ensembl release 89: ENSG00000182636, ENSG00000288364 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033585 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ MacDonald HR, Wevrick R (January 1998). "The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse". Hum Mol Genet. 6 (11): 1873–8. doi:10.1093/hmg/6.11.1873. PMID 9302265.
  6. ^ a b "Entrez Gene: NDN necdin homolog (mouse)".
  7. ^ Uniprot
  8. ^ Taniura H, Taniguchi N, Hara M, Yoshikawa K (January 1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. doi:10.1074/jbc.273.2.720. PMID 9422723.
  9. ^ a b Kuwako K, Taniura H, Yoshikawa K (January 2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi:10.1074/jbc.M308454200. PMID 14593116.
  10. ^ Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. doi:10.1002/jcb.10047. PMID 11813259. S2CID 5988824.
  11. ^ Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM (August 2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. Bibcode:2003PNAS..10010008H. doi:10.1073/pnas.1737765100. PMC 187743. PMID 12913118.
  12. ^ Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (April 2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. doi:10.1523/JNEUROSCI.23-08-03209.2003. PMC 6742322. PMID 12716928.
  13. ^ Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M (December 2002). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi:10.1074/jbc.C200533200. PMID 12414813.
  14. ^ Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798.
  15. ^ Taniura H, Matsumoto K, Yoshikawa K (June 1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. doi:10.1074/jbc.274.23.16242. PMID 10347180.

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