NPR2
Identifiers
Aliases	NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2, GCB, AMD1, GC-B
External IDs	OMIM: 108961 MGI: 97372 HomoloGene: 2970 GeneCards: NPR2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 35,791,003 bp[1] End 35,809,732 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 23.05 cM Start 43,631,935 bp[2] End 43,651,244 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary canal of the cervix ascending aorta stromal cell of endometrium left uterine tube tibial nerve left coronary artery right coronary artery gastric mucosa Top expressed in soleus muscle ankle extraocular muscle median eminence cumulus cell spinal ganglia cerebellar cortex superior frontal gyrus digastric muscle calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase activity nucleotide binding hormone binding GTP binding lyase activity identical protein binding phosphorus-oxygen lyase activity ATP binding guanylate cyclase activity natriuretic peptide receptor activity peptide hormone binding protein binding adenylate cyclase activity peptide receptor activity Cellular component integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble integral component of plasma membrane intracellular anatomical structure Biological process negative regulation of meiotic cell cycle regulation of cardiac conduction intracellular signal transduction ossification negative regulation of oocyte maturation cyclic nucleotide biosynthetic process regulation of blood pressure cGMP biosynthetic process protein phosphorylation cellular response to granulocyte macrophage colony-stimulating factor stimulus bone development receptor guanylyl cyclase signaling pathway reproductive process positive regulation of cGMP-mediated signaling cGMP-mediated signaling signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4882 230103 Ensembl ENSG00000159899 ENSMUSG00000028469 UniProt P20594 Q6VVW5 RefSeq (mRNA) NM_000907 NM_003995 NM_001378923 NM_173788 NM_001355466 RefSeq (protein) NP_003986 NP_001365852 NP_776149 NP_001342395 Location (UCSC) Chr 9: 35.79 – 35.81 Mb Chr 4: 43.63 – 43.65 Mb PubMed search [3] [4]
Wikidata
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Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), also known as NPR2, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR2 gene.^[5]

A mutation of the NPR2 gene can result in disproportionate dwarfism with short limbs.^[6]