NSP6 (rotavirus)

Gene 11 of Rotavirus encodes a nonstructural protein, NSP5 and also encodes NSP6, from an out of phase open reading frame.[1] In contrast to the other rotavirus non-structural proteins, NSP6 was found to have a high rate of turnover, being completely degraded within 2h of synthesis. NSP6 was found to be a sequence independent nucleic acid binding protein, with similar affinities for ssRNA and dsRNA.[2]


  1. ^ Mohan KV, Atreya CD (December 2001). "Nucleotide sequence analysis of rotavirus gene 11 from two tissue culture-adapted ATCC strains, RRV and Wa". Virus Genes. 23 (3): 321–9. doi:10.1023/A:1012577407824. PMID 11778700. S2CID 21538632.
  2. ^ Rainsford EW, McCrae MA (December 2007). "Characterization of the NSP6 protein product of rotavirus gene 11". Virus Research. 130 (1–2): 193–201. doi:10.1016/j.virusres.2007.06.011. PMID 17658646.