Protein-coding gene in the species Homo sapiens
NOP2/Sun domain family, member 2 is a protein that in humans is encoded by the NSUN2 gene.[5] Alternatively spliced transcript variants encoding different isoforms have been noted for the gene.
Function
The protein is a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA (Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA.[5] NSUN2 is also localized on mitochondria and is capable of introducing post-transcriptional modifications in mitochondrial tRNAs.[6][7]
Clinical relevance
Mutations in this gene have been found associated to cases of Dubowitz-like syndrome.[8]