Protein-coding gene in the species Homo sapiens
NUDT3 |
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Identifiers |
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Aliases | NUDT3, DIPP, DIPP-1, DIPP1, nudix hydrolase 3 |
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External IDs | OMIM: 609228 MGI: 1928484 HomoloGene: 31400 GeneCards: NUDT3 |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - inferior olivary nucleus
- postcentral gyrus
- Brodmann area 46
- Brodmann area 10
- middle frontal gyrus
- Region I of hippocampus proper
- external globus pallidus
- entorhinal cortex
- internal globus pallidus
- frontal pole
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| Top expressed in | - entorhinal cortex
- superior frontal gyrus
- cingulate gyrus
- primary motor cortex
- prefrontal cortex
- hippocampus proper
- cerebellar cortex
- superior colliculus
- ganglionic eminence
- blood
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function |
- inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
- inositol diphosphate tetrakisphosphate diphosphatase activity
- inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
- hydrolase activity
- diphosphoinositol-polyphosphate diphosphatase activity
- inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
- metal ion binding
- inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
- inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
- magnesium ion binding
- inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
- inositol diphosphate pentakisphosphate diphosphatase activity
- inositol bisdiphosphate tetrakisphosphate diphosphatase activity
- endopolyphosphatase activity
- bis(5'-adenosyl)-hexaphosphatase activity
- bis(5'-adenosyl)-pentaphosphatase activity
- m7G(5')pppN diphosphatase activity
| Cellular component | | Biological process | | Sources:Amigo / QuickGO |
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Wikidata |
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Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.[5][6]
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998).[supplied by OMIM][6]