Protein-coding gene in the species Homo sapiens
NUDT4 |
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Identifiers |
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Aliases | NUDT4, DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, nudix hydrolase 4, DIPP-2B, NUDT4B |
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External IDs | OMIM: 609229 MGI: 1918457 HomoloGene: 41726 GeneCards: NUDT4 |
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Gene ontology |
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Molecular function |
- inositol diphosphate tetrakisphosphate diphosphatase activity
- inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
- inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
- inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
- metal ion binding
- protein binding
- RNA binding
- inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
- hydrolase activity
- diphosphoinositol-polyphosphate diphosphatase activity
- inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
- inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
- inositol diphosphate pentakisphosphate diphosphatase activity
- inositol bisdiphosphate tetrakisphosphate diphosphatase activity
- endopolyphosphatase activity
- bis(5'-adenosyl)-hexaphosphatase activity
- bis(5'-adenosyl)-pentaphosphatase activity
- m7G(5')pppN diphosphatase activity
- snoRNA binding
| Cellular component | | Biological process | | Sources:Amigo / QuickGO |
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Wikidata |
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Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.[5][6][7]
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.[7]