Nathan Kuppermann
EducationStanford University(BSc Biology)

06/1981

University of California San Francisco(MD)

06/1985

Harvard University(MPH Public Health)

06/1993
Occupation(s)Associate Dean for Global Health, UC Davis School of Medicine and UC Davis Health

Distinguished Professor, UC Davis School of Medicine

Professor and Endowed Chair, Emergency Medicine, UC Davis School of Medicine

Nathan Kuppermann is an American pediatrician and emergency physician who is a member of the National Academy of Medicine. He serves as a distinguished professor in the Departments of Emergency Medicine and Pediatrics at the UC Davis School of Medicine,[1] educating future physicians about the fields he is adept in. Additionally, he holds the esteemed Bo Tomas Brofeldt Endowed Chair in emergency medicine.[2] Dr. Kuppermann has made many notable contributions as the founding chair of the Pediatric Emergency Care Applied Research Network (PECARN),[3] and subsequently as the chair of the global Pediatric Emergency Research Network (PERN).[4][5] His contributions to pediatric emergency research and care highlights his dedication to improving the well-being of young patients across the world.  

Education

Kuppermann received his B.SC in Biology at Stanford University.[6] He completed his Doctorate in Medicine at the University of California, San Francisco School of Medicine[7] and continued on to Harvard University, School of Public Health for his Masters in Public Health.[8]

Academic work

He is both a pediatric emergency physician and clinical epidemiologist. Kuppermann has been a federally-funded investigator[9][10][11] for many years and has particular interests in the clinical efficiency and utility of laboratory testing in the setting of the Pediatric Emergency Department.[12] His research has specially emphasized the laboratory evaluation of young febrile children[13], evaluation of children at risk of diabetic ketoacidosis-related cerebral edema[14] and laboratory and radiographic evaluation of the pediatric trauma patient.

Early Research

Kuppermann’s early research addressed the identification of young children presenting to the emergency department (ED) with infectious emergencies.[15] These studies focused on distinguishing young febrile children with serious bacterial infections (SBIs) from those with viral illnesses.[16][17] His studies derived and validated prediction rules in order to aid ED clinicians in risk stratifying infants at low and high-risk of SBIs, and his studies centered on meningitis, bacteremia, and urinary tract infections[18]. 

Notable Contributions to Research

Kuppermann has extensive experience performing large, multicenter randomized controlled trials and observational studies pertaining to pediatric trauma.

Kuppermann has been studying trauma in children for over 20 years and has been particularly active in research pertaining to traumatic brain injuries (TBI) in children. In an important study headed by Kuppermann,[19] he enrolled ~45,000 children that experience head trauma to discover how to greatly reduce radiation exposure caused by unnecessary CT scans. This was done by determining the risk of pediatric TBIs from relevant predictive factors which gives providers more insight whether or not a CT scan is warranted. Similarly, Kuppermann has served as senior investigator/co-PI in research pertaining to pediatric abdominal trauma[20] through which he derived a highly accurate prediction rule for CT use, the largest of which enrolled >12,000 children with abdominal trauma. The CT prediction rule is now widely practiced today.

His other notable research pertains to diabetic ketoacidosis (DKA) in children,[21][22][23] and he has been involved in this research for over 20 years. He has served as a PI and Primary co-I on several extramural grants related to DKA and cerebral injury/edema in children, and one of his earliest research collaborations of the topic resulted in a highly-cited publication in the New England Journal of Medicine.[21]

Kuppermann's >300 publications has been cited roughly 20 thousand times and has an h-index of 74.[24]

Professional Service

Kuppermann has been a leader in multicenter research in emergency services for children, and he has worked to increase the evidence base in pediatric emergency medicine. He served as the Chair of the Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC) of the American Academy of Pediatrics from 1996-2000. Through this committee, he conducted various research studies in which thousands of children were enrolled.

Kuppermann was Chair of the Steering Committee of PECARN since its inception in 2001 until late in 2008.[3] This network is funded by HRSA/MCHB and EMSC and consists of 22 geographically and demographically diverse hospital pediatric emergency departments which evaluate ~ 1,300,000 children annually. Since its creation, PECARN has published more than 200 peer-reviewed publications and secured more than $150 million in extramural funding,[25] and from 2019-2023, Kuppermann was re-funded to participate in PECARN with a $2.8 million award. As a leader of PECARN, his work has helped shape the future concerning pediatric emergency care and advanced the ability to perform large-scale, multicenter research across the country.[26]

Dr. Kuppermann has been working with and supporting a health clinic in Kathmandu, Nepal since 1987[27] and has returned many times. He has worked clinically there, has served as an educator and fund-raiser, and participated in acute earthquake medical relief in 2015. In 2021 he helped found a non-profit "Friends for Health Nepal”(FFHN),[27] which he serves as president, to help support the clinic.  

Notable Ongoing Projects

Most currently, Kuppermann has investigated novel biomarkers and measured the host response to distinguish viral from bacterial infections in young febrile infants.[18]

Ongoing Projects:

A randomized controlled trial of abdominal ultrasound (FAST) in children with blunt torso trauma[28]

09/07/2022 – 08/31/2027

Headache Assessment of Children for Emergent Intracranial Abnormalities[29]

07/01/2020 – 06/30/2025

PRagMatic Pediatric Trial of Balanced versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS)[30]

04/01/2020 – 03/31/2025

Emergency Medical Service for Children Network Development[31]

9/01/2019 – 8/31/2023

RNA Biosignatures: A Paradigm Change for the Management of Febrile Infants[32]

8/21/2015 – 4/30/2023

Awards and honors

Maureen Andrew Mentor Award, Society for Pediatric Research(2022)[33]

Hibbard Williams Extraordinary Achievement Award(2020)[34]

Faculty Distinguished Research Award, UC Davis(2020)[35]

Chancellor’s Departmental Achievement Award for Diversity and Community for Emergency Medicine(2020)[36]

Dean’s Team Award for Excellence for the Pediatric Emergency Care Applied Research Network (PECARN), UC Davis School of Medicine(2018)[37]

Distinguished Professor, UC Davis School of Medicine(2018)

Inaugural winner of SAEM Scientific Mentoring Award in Pediatric Emergency Medicine(2017)

Dean’s Team Award for Excellence in Mentoring, UC Davis School of Medicine(2017)

UC Davis School of Medicine Research Award(2016)[38]

Best Scientific Abstract, American Academy of Pediatrics Section on Emergency Medicine(2015)

American College of Emergency Physicians (ACEP) EBSCO/PEMSoft Achievement Award(2015)[39]

Ludwig-Seidel Award, American Academy of Pediatrics(2012)[40]

Best Scientific Abstract, American Academy of Pediatrics Section on Emergency Medicine(2012)

Best Scientific Paper, American Academy of Pediatrics Section on Emergency Medicine(2011)

American College of Emergency Physicians Outstanding Research Award(2011)[41]

Elected to the National Academy of Medicine(Institute of Medicine)(2010)[41]

EMSC National Hero’s Award: Outstanding Research Project(2010)[42]

Society for Academic Emergency Medicine (SAEM) Excellence in Research Award(2010)[43]

Miller-Sarkin Mentoring award, Academic Pediatric Association(2009)[44]

Dean’s Excellence in Research Award, UC Davis School of Medicine(2008)[45]

Willis Wingert Award (mentor for Best Scientific Paper by a Trainee), EM, AAP(2008)

Pediatric Emergency Medicine and Critical Care Research Award, AAP(2008)

Emergency Medical Service for Children (EMSC) National Hero’s Award: Outstanding Research(2007)[46]

Outstanding Contribution to Faculty Development and Diversity, UC Davis School of Med(2007)

Pediatric Emergency Medicine and Critical Care Research Award(2006)

Dean’s Team Award for Excellence in Mentoring, UC Davis School of Medicine(2003)[47]

Fulbright Distinguished Scholar, U.K.(2003)[48]

Pediatric Emergency Medicine and Critical Care Research Award(2002)

Outstanding Consultant, Annals of Emergency Medicine(2000)

Academic Teacher of the Year Award, Emergency Medicine, UC Davis School of Medicine(2000)

Outstanding Faculty Clinical Instructor, UC Davis School of Medicine(1998)

The Role Model Award, Department of Pediatrics, UC Davis School of Medicine(1997, 1999)

Pediatric Emergency Medicine and Critical Care Research Award, AAP(1996)

Fellow’s Teaching Award, Children’s Hospital, Boston, MA(1992)

Outstanding Teaching Resident Award, Dept of Pediatrics, Harbor-UCLA, Torrance, CA(1987, 1989)

Alpha Omega Alpha Medical Honor Society, UC San Francisco School of Medicine(1985)

References

  1. ^ "Professor Kuppermann".
  2. ^ Jones, Dave (2010-07-16). "LAURELS: 'National hero' doc and a Wikimedia board member". UC Davis. Retrieved 2023-06-02.
  3. ^ a b MD, Bryn Dhir, Jason Woods (2020-01-07). "PECARN: Its relevance and importance in pediatric emergency care". ALiEM. Retrieved 2023-06-02.((cite web)): CS1 maint: multiple names: authors list (link)
  4. ^ News. "Emergency medicine chair receives prestigious mentor award". news. Retrieved 2023-06-02. ((cite web)): |last= has generic name (help)
  5. ^ "Announcement - New Chair for the Pediatric Emergency Research Networks". TREKK.ca. Retrieved 2023-06-02.
  6. ^ "physicians/ucdavis".
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  9. ^ Kuppermann, Nathan; Holmes, James. "DANGER: Developing the Next Generation of Emergency Medicine Researchers". ((cite journal)): Cite journal requires |journal= (help)
  10. ^ Kuppermann, Nathan; Nishijima, Daniel. "Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC)". ((cite journal)): Cite journal requires |journal= (help)
  11. ^ Holmes, James; Kuppermann, Nathan. "Validation of Decision Rules for CT Use in Children with Abdominal or Head Trauma". ((cite journal)): Cite journal requires |journal= (help)
  12. ^ Newgard, Craig D.; Lin, Amber; Olson, Lenora M.; Cook, Jennifer N. B.; Gausche-Hill, Marianne; Kuppermann, Nathan; Goldhaber-Fiebert, Jeremy D.; Malveau, Susan; Smith, McKenna; Dai, Mengtao; Nathens, Avery B. (2021-09-01). "Evaluation of Emergency Department Pediatric Readiness and Outcomes Among US Trauma Centers". JAMA Pediatrics. 175 (9): 947–956. doi:10.1001/jamapediatrics.2021.1319. ISSN 2168-6211. PMC 8185631. PMID 34096991.
  13. ^ Pantell, Robert H.; Roberts, Kenneth B.; Adams, William G.; Dreyer, Benard P.; Kuppermann, Nathan; O'Leary, Sean T.; Okechukwu, Kymika; Woods, Charles R.; SUBCOMMITTEE ON FEBRILE INFANTS (August 2021). "Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old". Pediatrics. 148 (2): e2021052228. doi:10.1542/peds.2021-052228. ISSN 1098-4275. PMID 34281996. S2CID 236139548.
  14. ^ University of California, Davis (2018-06-19). "Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis". Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). ((cite journal)): Cite journal requires |journal= (help)
  15. ^ Kuppermann, Nathan; Malley, Richard; Inkelis, Stanley H.; Fleisher, Gary R. (1999-02-01). "Clinical and Hematologic Features Do Not Reliably Identify Children With Unsuspected Meningococcal Disease". Pediatrics. 103 (2): e20. doi:10.1542/peds.103.2.e20. ISSN 1098-4275. PMID 9925866.
  16. ^ Nigrovic, Lise E.; Kuppermann, Nathan; Macias, Charles G.; Cannavino, Christopher R.; Moro-Sutherland, Donna M.; Schremmer, Robert D.; Schwab, Sandra H.; Agrawal, Dewesh; Mansour, Karim M.; Bennett, Jonathan E.; Katsogridakis, Yiannis L.; Mohseni, Michael M.; Bulloch, Blake; Steele, Dale W.; Kaplan, Ron L. (2007-01-03). "Clinical Prediction Rule for Identifying Children With Cerebrospinal Fluid Pleocytosis at Very Low Risk of Bacterial Meningitis". JAMA. 297 (1): 52–60. doi:10.1001/jama.297.1.52. ISSN 0098-7484. PMID 17200475.
  17. ^ Mahajan, Prashant; Kuppermann, Nathan; Mejias, Asuncion; Suarez, Nicolas; Chaussabel, Damien; Casper, T. Charles; Smith, Bennett; Alpern, Elizabeth R.; Anders, Jennifer; Atabaki, Shireen M.; Bennett, Jonathan E.; Blumberg, Stephen; Bonsu, Bema; Borgialli, Dominic; Brayer, Anne (2016-08-23). "Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger". JAMA. 316 (8): 846–857. doi:10.1001/jama.2016.9207. ISSN 0098-7484. PMC 5122927. PMID 27552618.
  18. ^ a b Kuppermann, Nathan; Dayan, Peter S.; Levine, Deborah A.; Vitale, Melissa; Tzimenatos, Leah; Tunik, Michael G.; Saunders, Mary; Ruddy, Richard M.; Roosevelt, Genie; Rogers, Alexander J.; Powell, Elizabeth C.; Nigrovic, Lise E.; Muenzer, Jared; Linakis, James G.; Grisanti, Kathleen (April 2019). "A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections". JAMA Pediatrics. 173 (4): 342–351. doi:10.1001/jamapediatrics.2018.5501. ISSN 2168-6203. PMC 6450281. PMID 30776077.
  19. ^ Kupermann, Nathan (September 15, 2009). "Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study". The Lancet. 374 (9696): 1160–1170. doi:10.1016/S0140-6736(09)61558-0. PMID 19758692. S2CID 43075627.
  20. ^ Holmes, James F.; Lillis, Kathleen; Monroe, David; Borgialli, Dominic; Kerrey, Benjamin T.; Mahajan, Prashant; Adelgais, Kathleen; Ellison, Angela M.; Yen, Kenneth; Atabaki, Shireen; Menaker, Jay; Bonsu, Bema; Quayle, Kimberly S.; Garcia, Madelyn; Rogers, Alexander; Blumberg, Stephen; Lee, Lois; Tunik, Michael; Kooistra, Joshua; Kwok, Maria; Cook, Lawrence J.; Dean, J. Michael; Sokolove, Peter E.; Wisner, David H.; Ehrlich, Peter; Cooper, Arthur; Dayan, Peter S.; Wootton-Gorges, Sandra; Kuppermann, Nathan; (August 2013). "Identifying Children at Very Low Risk of Clinically Important Blunt Abdominal Injuries". Annals of Emergency Medicine. 62 (2): 107–116.e2. doi:10.1016/j.annemergmed.2012.11.009. ISSN 0196-0644. PMID 23375510.
  21. ^ a b Kuppermann, Nathan; Ghetti, Simona; Schunk, Jeff E.; Stoner, Michael J.; Rewers, Arleta; McManemy, Julie K.; Myers, Sage R.; Nigrovic, Lise E.; Garro, Aris; Brown, Kathleen M.; Quayle, Kimberly S.; Trainor, Jennifer L.; Tzimenatos, Leah; Bennett, Jonathan E.; DePiero, Andrew D. (2018-06-14). "Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis". The New England Journal of Medicine. 378 (24): 2275–2287. doi:10.1056/NEJMoa1716816. ISSN 0028-4793. PMC 6051773. PMID 29897851.
  22. ^ Glaser, Nicole S.; Wootton-Gorges, Sandra L.; Buonocore, Michael H.; Tancredi, Daniel J.; Marcin, James P.; Caltagirone, Ryan; Lee, Yvonne; Murphy, Christopher; Kuppermann, Nathan (January 2013). "Subclinical Cerebral Edema in Children With Diabetic Ketoacidosis Randomized to 2 Different Rehydration Protocols". Pediatrics. 131 (1): e73–e80. doi:10.1542/peds.2012-1049. ISSN 0031-4005. PMC 3529948. PMID 23230065.
  23. ^ Myers, Sage R.; Glaser, Nicole S.; Trainor, Jennifer L.; Nigrovic, Lise E.; Garro, Aris; Tzimenatos, Leah; Quayle, Kimberly S.; Kwok, Maria Y.; Rewers, Arleta; Stoner, Michael J.; Schunk, Jeff E.; McManemy, Julie K.; Brown, Kathleen M.; DePiero, Andrew D.; Olsen, Cody S.;; Casper, Charles T.; Ghetti, Simona; Kuppermann, Nathan; (2020-12-04). "Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes". JAMA Network Open. 3 (12): e2025481. doi:10.1001/jamanetworkopen.2020.25481. ISSN 2574-3805. PMC 7718599. PMID 33275152.
  24. ^ "Nathan Kuppermann". scholar.google.com. Retrieved 2023-05-19.
  25. ^ Tzimenatos, Leah; Kim, Emily; Kuppermann, Nathan (January 2015). "The Pediatric Emergency Care Applied Research Network". Pediatric Emergency Care. 31 (1): 70–76. doi:10.1097/pec.0000000000000303. ISSN 0749-5161. PMID 25560626. S2CID 16389086.
  26. ^ Pediatric Emergency Care Applied Research Network (2008-06-28). "The Pediatric Emergency Care Applied Research Network (PECARN): Rationale, Development, and First Steps*". Academic Emergency Medicine. 10 (6): 661–668. doi:10.1111/j.1553-2712.2003.tb00053.x. ISSN 1069-6563. PMID 12782530.
  27. ^ a b "Partners – Friends Of Shanta Bhawan, Nepal". Retrieved 2023-06-02.
  28. ^ Holmes, James F.; Kelley, Kenneth M.; Wootton-Gorges, Sandra L.; Utter, Garth H.; Abramson, Lisa P.; Rose, John S.; Tancredi, Daniel J.; Kuppermann, Nathan (2017-06-13). "Effect of Abdominal Ultrasound on Clinical Care, Outcomes, and Resource Use Among Children With Blunt Torso Trauma: A Randomized Clinical Trial". JAMA. 317 (22): 2290–2296. doi:10.1001/jama.2017.6322. ISSN 1538-3598. PMC 5815005. PMID 28609532.
  29. ^ "Headache Assessment of Children for Emergent Intracranial Abnormalities - Dimensions". app.dimensions.ai. Retrieved 2023-05-19.
  30. ^ Weiss, Scott L.; Balamuth, Fran; Long, Elliot; Thompson, Graham C.; Hayes, Katie L.; Katcoff, Hannah; Cook, Marlena; Tsemberis, Elena; Hickey, Christopher P.; Williams, Amanda; Williamson-Urquhart, Sarah; Borland, Meredith L.; Dalziel, Stuart R.; Gelbart, Ben; Freedman, Stephen B.; Babl, Franz E.; Huang, Jing; Kuppermann, Nathan; (2021-11-06). "PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial". Trials. 22 (1): 776. doi:10.1186/s13063-021-05717-4. ISSN 1745-6215. PMC 8572061. PMID 34742327.
  31. ^ Klassen, Terry P.; Dalziel, Stuart R.; Babl, Franz E.; Benito, Javier; Bressan, Silvia; Chamberlain, James; Chang, Todd P.; Freedman, Stephen B.; Kohn Loncarica, Guillermo; Lyttle, Mark D.; Mintegi, Santiago; Mistry, Rakesh D.; Nigrovic, Lise E.; Oostenbrink, Rianne; Plint, Amy C.; Rino, Pedro; Roland, Damian; Van de Mosselaer, Greg; Kuppermann, Nathan; (October 2021). "The Pediatric Emergency Research Network (PERN): A decade of global research cooperation in paediatric emergency care". Emergency Medicine Australasia: EMA. 33 (5): 900–910. doi:10.1111/1742-6723.13801. ISSN 1742-6723. PMID 34218513. S2CID 235734242.
  32. ^ Mahajan, Prashant; Kuppermann, Nathan; Mejias, Asuncion; Suarez, Nicolas; Chaussabel, Damien; Casper, T. Charles; Smith, Bennett; Alpern, Elizabeth R.; Anders, Jennifer; Atabaki, Shireen M.; Bennett, Jonathan E.; Blumberg, Stephen; Bonsu, Bema; Borgialli, Dominic; Brayer, Anne (23–30 August 2016). "Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger". JAMA. 316 (8): 846–857. doi:10.1001/jama.2016.9207. ISSN 1538-3598. PMC 5122927. PMID 27552618.
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