This is a list of the National Register of Historic Places listings in Cape Girardeau County, Missouri.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in Cape Girardeau County, Missouri, United States. Latitude and longitude coordinates are provided for many National Register properties and districts; these locations may be seen together in a map.^[1]

There are 60 properties and districts listed on the National Register in the county.

          This National Park Service list is complete through NPS recent listings posted February 23, 2024.^[2]

Current listings

[3]	Name on the Register	Image	Date listed[4]	Location	City or town	Description
1	B'Nai Israel Synagogue		May 5, 2004 (#04000385)	121 S. Main St. 37°18′04″N 89°31′09″W / 37.301111°N 89.519167°W / 37.301111; -89.519167 (B'Nai Israel Synagogue)	Cape Girardeau
2	Bainbridge Ferry	Upload image	June 21, 2007 (#07000573)	County Road 630 37°24′43″N 89°26′16″W / 37.411944°N 89.437778°W / 37.411944; -89.437778 (Bainbridge Ferry)	Cape Girardeau
3	Bainbridge Ferry Rd.	Upload image	June 21, 2007 (#07000577)	County Road 623 37°26′11″N 89°28′07″W / 37.436517°N 89.468747°W / 37.436517; -89.468747 (Bainbridge Ferry Rd.)	Cape Girardeau
4	Bennett-Tobler-Pace-Oliver House		April 18, 1985 (#85000853)	224 E. Adams 37°22′54″N 89°39′56″W / 37.381667°N 89.665556°W / 37.381667; -89.665556 (Bennett-Tobler-Pace-Oliver House)	Jackson
5	Big Hill Farmstead Historic District	Upload image	December 22, 1999 (#99001598)	2246 Route PP 37°21′49″N 89°41′26″W / 37.363611°N 89.690556°W / 37.363611; -89.690556 (Big Hill Farmstead Historic District)	Jackson
6	Broadway Commercial Historic District	More images	September 6, 2016 (#15001017)	600, 700 & 800 blocks of Broadway & 210 N. Ellis St. 37°18′24″N 89°31′39″W / 37.306789°N 89.527404°W / 37.306789; -89.527404 (Broadway Commercial Historic District)	Cape Girardeau
7	Broadway Theatre		June 15, 2015 (#15000354)	805 Broadway St. 37°18′24″N 89°31′42″W / 37.306667°N 89.528472°W / 37.306667; -89.528472 (Broadway Theatre)	Cape Girardeau
8	Broadway and North Fountain Street Historic District	More images	July 15, 2003 (#03000654)	320-400 Broadway St. and 221 N. Fountain St. 37°18′23″N 89°31′20″W / 37.306389°N 89.522222°W / 37.306389; -89.522222 (Broadway and North Fountain Street Historic District)	Cape Girardeau
9	Broadway-Middle Commercial Historic District		July 24, 2007 (#07000753)	500 block of Broadway St. and 100 block of N. Middle St.; also south side 400 block of Broadway 37°18′24″N 89°31′27″W / 37.306667°N 89.524167°W / 37.306667; -89.524167 (Broadway-Middle Commercial Historic District)	Cape Girardeau	Second set of boundaries represents a boundary increase of September 4, 2013
10	Burfordville Covered Bridge	More images	May 19, 1970 (#70000325)	Eastern edge of Burfordville on County Road HH 37°22′02″N 89°48′09″W / 37.367222°N 89.8025°W / 37.367222; -89.8025 (Burfordville Covered Bridge)	Burfordville
11	Burfordville Mill	More images	May 27, 1971 (#71000463)	Off Route 34 37°22′05″N 89°48′06″W / 37.368056°N 89.801667°W / 37.368056; -89.801667 (Burfordville Mill)	Burfordville
12	Abraham Byrd House	More images	June 21, 2007 (#07000572)	2832 County Road 442 37°27′05″N 89°41′58″W / 37.451389°N 89.699444°W / 37.451389; -89.699444 (Abraham Byrd House)	Jackson
13	Cape Girardeau Commercial Historic District		July 20, 2000 (#00000820)	100 block of N. Main and the 100 block of Broadway Sts.; also 101 N. Main St.; also 127 N. Water St. 37°18′20″N 89°31′06″W / 37.305556°N 89.518333°W / 37.305556; -89.518333 (Cape Girardeau Commercial Historic District)	Cape Girardeau	101 N. Main and 127 N. Water represent boundary increases of July 11, 2007 and August 29, 2008 respectively
14	Cape Girardeau Court of Common Pleas	More images	October 25, 2010 (#10000856)	44 N. Lorimier St. 37°18′18″N 89°31′12″W / 37.305°N 89.52°W / 37.305; -89.52 (Cape Girardeau Court of Common Pleas)	Cape Girardeau
15	Central High School		July 18, 2008 (#08000663)	101 S. Pacific St. 37°18′12″N 89°31′50″W / 37.303333°N 89.530556°W / 37.303333; -89.530556 (Central High School)	Cape Girardeau
16	Dr. Jean Chapman House	More images	March 15, 2016 (#16000084)	1150 N. Henderson Ave. 37°19′12″N 89°31′57″W / 37.320063°N 89.532561°W / 37.320063; -89.532561 (Dr. Jean Chapman House)	Cape Girardeau
17	George Boardman Clark House		July 22, 1994 (#94000738)	6 S. Fountain St. 37°18′12″N 89°31′20″W / 37.303333°N 89.522222°W / 37.303333; -89.522222 (George Boardman Clark House)	Cape Girardeau
18	Courthouse-Seminary Neighborhood Historic District	More images	September 9, 2010 (#10000723)	Roughly bounded by Middle St., Themis St., Main St., Aquamsi St., and Morgan Oaks St. 37°18′05″N 89°31′17″W / 37.301389°N 89.521389°W / 37.301389; -89.521389 (Courthouse-Seminary Neighborhood Historic District)	Cape Girardeau
19	Erlbacher Buildings		July 8, 2009 (#09000502)	1105 and 1107 Broadway St. 37°18′30″N 89°31′56″W / 37.308333°N 89.532222°W / 37.308333; -89.532222 (Erlbacher Buildings)	Cape Girardeau
20	Esquire Theater	More images	September 15, 2005 (#05001025)	824 Broadway St. 37°18′26″N 89°31′45″W / 37.307222°N 89.529028°W / 37.307222; -89.529028 (Esquire Theater)	Cape Girardeau
21	First Baptist Church	Upload image	June 27, 2023 (#100009100)	200 Broadway St. 37°18′22″N 89°31′10″W / 37.3061°N 89.5194°W / 37.3061; -89.5194 (First Baptist Church)	Cape Girardeau
22	Fort D	More images	August 1, 2019 (#100004219)	920 Fort St. 37°17′27″N 89°31′35″W / 37.2909°N 89.5263°W / 37.2909; -89.5263 (Fort D)	Cape Girardeau
23	Frizel-Welling House		June 25, 1999 (#99000742)	209 W. Main St. 37°22′57″N 89°40′10″W / 37.3825°N 89.669444°W / 37.3825; -89.669444 (Frizel-Welling House)	Jackson
24	Glenn House		October 11, 1979 (#79001354)	325 S. Spanish St. 37°17′53″N 89°31′14″W / 37.298056°N 89.520556°W / 37.298056; -89.520556 (Glenn House)	Cape Girardeau
25	Green's Ferry	Upload image	June 21, 2007 (#07000571)	On the Mississippi River at the end of Green's Ferry Rd.[5] 37°27′04″N 89°27′27″W / 37.451111°N 89.457500°W / 37.451111; -89.457500 (Green's Ferry)	Cape Girardeau
26	Haarig Commercial Historic District		July 20, 2000 (#00000819)	Along sections of the 600 block of Good Hope St. and 300 block of S. Sprigg St. 37°17′58″N 89°31′38″W / 37.299444°N 89.527222°W / 37.299444; -89.527222 (Haarig Commercial Historic District)	Cape Girardeau
27	Hanover Lutheran Church		September 14, 1987 (#87001575)	2949 Perryville Rd. 37°21′10″N 89°33′37″W / 37.352778°N 89.560278°W / 37.352778; -89.560278 (Hanover Lutheran Church)	Cape Girardeau
28	William Henry and Lilla Luce Harrison House		December 6, 2005 (#05001375)	313 Themis St. 37°18′17″N 89°31′17″W / 37.304722°N 89.521500°W / 37.304722; -89.521500 (William Henry and Lilla Luce Harrison House)	Cape Girardeau
29	Himmelberger and Harrison Building		July 17, 2003 (#03000653)	400 Broadway St. 37°18′24″N 89°31′21″W / 37.306667°N 89.522500°W / 37.306667; -89.522500 (Himmelberger and Harrison Building)	Cape Girardeau
30	House at 323 Themis Street		June 27, 1997 (#97000629)	323 Themis St. 37°18′18″N 89°31′19″W / 37.305000°N 89.521806°W / 37.305000; -89.521806 (House at 323 Themis Street)	Cape Girardeau
31	Huhn-Harrison House		June 27, 2002 (#02000699)	340 S. Lorimier St. 37°17′52″N 89°31′18″W / 37.297778°N 89.521667°W / 37.297778; -89.521667 (Huhn-Harrison House)	Cape Girardeau
32	Jackson Uptown Commercial Historic District		February 1, 2006 (#05001562)	Roughly bounded by Court, Main, Missouri, and High Sts. 37°22′57″N 89°40′06″W / 37.3825°N 89.668436°W / 37.3825; -89.668436 (Jackson Uptown Commercial Historic District)	Jackson
33	Jefferson School		May 12, 2009 (#09000300)	731 Jefferson Ave. 37°17′49″N 89°31′45″W / 37.296944°N 89.529167°W / 37.296944; -89.529167 (Jefferson School)	Cape Girardeau
34	Kage School		September 29, 2005 (#05001090)	3110 Kage Rd. 37°19′57″N 89°34′45″W / 37.3325°N 89.579167°W / 37.3325; -89.579167 (Kage School)	Cape Girardeau
35	Klostermann Block		July 22, 1994 (#94000739)	7, 9, 11, 13, and 15 S. Spanish St. 37°18′11″N 89°31′11″W / 37.303056°N 89.519722°W / 37.303056; -89.519722 (Klostermann Block)	Cape Girardeau
36	Edward S. and Mary Annatoile Albert Lilly House		June 20, 2008 (#08000535)	129 S. Lorimier St. 37°18′05″N 89°31′18″W / 37.301389°N 89.521667°W / 37.301389; -89.521667 (Edward S. and Mary Annatoile Albert Lilly House)	Cape Girardeau
37	Main-Spanish Commercial Historic District		December 30, 2008 (#08001259)	Roughly the 100 blocks of Main and Spanish Sts. and adjacent portions of Themis and Independence Sts. 37°18′16″N 89°31′08″W / 37.304444°N 89.518889°W / 37.304444; -89.518889 (Main-Spanish Commercial Historic District)	Cape Girardeau
38	Marquette Hotel		April 11, 2002 (#02000356)	338 Broadway St. 37°18′24″N 89°31′19″W / 37.306667°N 89.521944°W / 37.306667; -89.521944 (Marquette Hotel)	Cape Girardeau
39	McKendree Chapel		April 13, 1987 (#06000042)	Off Interstate 55; also the southern side of Bainbridge Rd., 0.5 miles west of Interstate 55 37°22′41″N 89°37′07″W / 37.378056°N 89.618611°W / 37.378056; -89.618611 (McKendree Chapel)	Jackson	Specific address represents a boundary increase of February 14, 2006
40	Miller-Seabaugh House and Dr. Seabaugh Office Building	Upload image	January 4, 1996 (#95001494)	341 Market St. 37°25′58″N 89°47′52″W / 37.432778°N 89.797778°W / 37.432778; -89.797778 (Miller-Seabaugh House and Dr. Seabaugh Office Building)	Millersville
41	Old Appleton Bridge		August 25, 2009 (#09000648)	Main St. over Apple Creek 37°35′52″N 89°42′50″W / 37.597639°N 89.71375°W / 37.597639; -89.71375 (Old Appleton Bridge)	Old Appleton
42	Old Lorimier Cemetery	More images	September 28, 2005 (#05001091)	500 N. Fountain St. 37°18′40″N 89°31′12″W / 37.311111°N 89.520000°W / 37.311111; -89.520000 (Old Lorimier Cemetery)	Cape Girardeau
43	Oliver-Leming House		September 12, 1980 (#80002323)	740 North St. 37°18′35″N 89°31′40″W / 37.309722°N 89.527778°W / 37.309722; -89.527778 (Oliver-Leming House)	Cape Girardeau
44	Abraham Russell Ponder House		March 27, 2008 (#08000226)	141 S. Louisiana Ave. 37°18′09″N 89°32′19″W / 37.302500°N 89.538611°W / 37.302500; -89.538611 (Abraham Russell Ponder House)	Cape Girardeau
45	Frederick W. and Mary Karau Pott House		June 25, 1999 (#99000745)	826 Themis St. 37°18′22″N 89°31′46″W / 37.306111°N 89.529444°W / 37.306111; -89.529444 (Frederick W. and Mary Karau Pott House)	Cape Girardeau
46	James Reynolds House		October 13, 1983 (#83003942)	623 N. Main St. 37°18′41″N 89°31′05″W / 37.311389°N 89.518056°W / 37.311389; -89.518056 (James Reynolds House)	Cape Girardeau
47	Shady Grove Cemetery	Upload image	June 27, 2022 (#100007826)	502 Cty. Rd. 211 37°15′53″N 89°37′34″W / 37.2647°N 89.6260°W / 37.2647; -89.6260 (Shady Grove Cemetery)	Gordonville vicinity
48	August and Amalia Shivelbine House		June 25, 1999 (#99000743)	303 S. Spanish St. 37°17′55″N 89°31′14″W / 37.298750°N 89.520556°W / 37.298750; -89.520556 (August and Amalia Shivelbine House)	Cape Girardeau
49	South Middle Street Historic District		October 14, 2009 (#09000829)	513 William St. and 202-230 and 203-229 S. Middle St. 37°18′00″N 89°31′29″W / 37.300000°N 89.524720°W / 37.300000; -89.524720 (South Middle Street Historic District)	Cape Girardeau
50	Southeast Missourian Building		June 1, 2005 (#05000509)	301 Broadway St. 37°18′22″N 89°31′16″W / 37.306111°N 89.521111°W / 37.306111; -89.521111 (Southeast Missourian Building)	Cape Girardeau
51	St. James A.M.E. Church		January 15, 2014 (#13001085)	516 North St. 37°18′34″N 89°31′26″W / 37.309543°N 89.523856°W / 37.309543; -89.523856 (St. James A.M.E. Church)	Cape Girardeau
52	St. Vincent De Paul Catholic Church	More images	April 12, 1982 (#82003131)	131 S. Main St. 37°18′03″N 89°31′10″W / 37.300833°N 89.519444°W / 37.300833; -89.519444 (St. Vincent De Paul Catholic Church)	Cape Girardeau
53	St. Vincent's College Building		September 30, 2005 (#05001092)	201 Morgan Oak St. 37°17′47″N 89°31′16″W / 37.296389°N 89.521111°W / 37.296389; -89.521111 (St. Vincent's College Building)	Cape Girardeau
54	Col George C. Thilenius House		April 14, 1983 (#83000974)	100 Longview Pl. 37°18′24″N 89°32′30″W / 37.306667°N 89.541667°W / 37.306667; -89.541667 (Col George C. Thilenius House)	Cape Girardeau
55	Trail of Tears State Park Archeological Site		December 2, 1970 (#70000326)	Address Restricted	Oriole	An archeological site in Trail of Tears State Park
56	Julius Vasterling Building		June 17, 2009 (#09000439)	633-637 Broadway St. 37°18′23″N 89°31′35″W / 37.306527°N 89.526527°W / 37.306527; -89.526527 (Julius Vasterling Building)	Cape Girardeau
57	Warehouse Row Historic District		December 4, 2004 (#04001285)	19 N. Water St. 37°18′20″N 89°31′04″W / 37.305556°N 89.517778°W / 37.305556; -89.517778 (Warehouse Row Historic District)	Cape Girardeau
58	Robert Felix and Elma Taylor Wichterich House		August 12, 1999 (#99000987)	300 Good Hope St. 37°17′57″N 89°31′19″W / 37.299305°N 89.522083°W / 37.299305; -89.522083 (Robert Felix and Elma Taylor Wichterich House)	Cape Girardeau
59	J. Maple and Grace Senne Wilson House		July 7, 2015 (#15000365)	344 N. Ellis St. 37°18′34″N 89°31′39″W / 37.309444°N 89.527500°W / 37.309444; -89.527500 (J. Maple and Grace Senne Wilson House)	Cape Girardeau
60	Wood Building		December 10, 2003 (#03001269)	1-3 S. Frederick and 605-607 Independence Sts. 37°18′14″N 89°31′33″W / 37.303889°N 89.525833°W / 37.303889; -89.525833 (Wood Building)	Cape Girardeau