This is a list of the National Register of Historic Places listings in Clay County, South Dakota.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in Clay County, South Dakota, United States. The locations of National Register properties and districts for which the latitude and longitude coordinates are included below, may be seen in a map.^[1]

There are 43 properties and districts listed on the National Register in the county. Another 2 properties were once listed but have since been removed.

          This National Park Service list is complete through NPS recent listings posted April 26, 2024.^[2]

Current listings

[3]	Name on the Register[4]	Image	Date listed[5]	Location	City or town	Description
1	Anderson Homestead	Upload image	March 30, 1978 (#78002543)	East of Hub City 42°57′45″N 96°48′23″W / 42.9625°N 96.806389°W / 42.9625; -96.806389 (Anderson Homestead)	Hub City
2	William Andre House	More images	October 31, 2002 (#02001284)	31256 452nd Ave. 42°51′29″N 97°09′35″W / 42.858175°N 97.159770°W / 42.858175; -97.159770 (William Andre House)	Gayville
3	Austin-Whittemore House	More images	October 18, 1972 (#72001225)	15 Austin Ave. 42°46′44″N 96°56′07″W / 42.7789°N 96.9353°W / 42.7789; -96.9353 (Austin-Whittemore House)	Vermillion	Now a local history museum.
4	Bluff Historic District	Upload image	June 23, 2016 (#16000415)	Oak Pl. and Court, Kidder, Church, and Bloomingdale Sts. 42°46′38″N 96°55′54″W / 42.777222°N 96.931667°W / 42.777222; -96.931667 (Bluff Historic District)	Vermillion
5	Bluff View Cemetery Chapel		May 31, 2006 (#06000458)	0.2 miles south of junction of Crawford Rd. and Pinehurst Dr. 42°46′25″N 96°54′20″W / 42.7736°N 96.9056°W / 42.7736; -96.9056 (Bluff View Cemetery Chapel)	Vermillion
6	Brookman House	Upload image	August 28, 2023 (#100009320)	404 Cottage Ave. 42°47′02″N 96°55′57″W / 42.7838°N 96.9324°W / 42.7838; -96.9324 (Brookman House)	Vermillion
7	Building at 125 Ohio St.	More images	February 14, 2002 (#02000021)	125 Ohio St. 43°00′31″N 97°06′25″W / 43.008591°N 97.106847°W / 43.008591; -97.106847 (Building at 125 Ohio St.)	Wakonda
8	Burbank School No. 10		July 5, 1996 (#96000740)	White St., 2 blocks north of the former Chicago, Milwaukee, St. Paul and Pacific railroad tracks. 42°44′53″N 96°49′41″W / 42.7481°N 96.8281°W / 42.7481; -96.8281 (Burbank School No. 10)	Burbank
9	Clay County Courthouse		August 18, 1983 (#83003005)	211 W. Main St. 42°46′47″N 96°56′08″W / 42.7797°N 96.9356°W / 42.7797; -96.9356 (Clay County Courthouse)	Vermillion
10	Colton House		November 19, 2007 (#07001210)	402 S. University St. 42°46′37″N 96°55′26″W / 42.7769°N 96.9239°W / 42.7769; -96.9239 (Colton House)	Vermillion
11	Downtown Vermillion Historic District		March 7, 2003 (#02001288)	Main St., roughly bounded by Market and Dakota Sts. 42°46′45″N 96°55′52″W / 42.7792°N 96.9311°W / 42.7792; -96.9311 (Downtown Vermillion Historic District)	Vermillion
12	First Baptist Church of Vermillion		March 5, 1982 (#82003921)	101 E. Main St. 42°46′44″N 96°55′49″W / 42.7789°N 96.9303°W / 42.7789; -96.9303 (First Baptist Church of Vermillion)	Vermillion
13	First Congregational Church, Vermillion	Upload image	July 16, 2021 (#100006723)	226 East Main St. 42°46′46″N 96°55′40″W / 42.7794°N 96.9279°W / 42.7794; -96.9279 (First Congregational Church, Vermillion)	Vermillion
14	First Methodist Episcopal Church		January 28, 2004 (#03001522)	14-16 North Dakota St. 42°46′46″N 96°55′46″W / 42.7794°N 96.9294°W / 42.7794; -96.9294 (First Methodist Episcopal Church)	Vermillion
15	First National Bank Building of Vermillion		February 13, 1986 (#86000244)	1 E. Main St. 42°46′45″N 96°55′54″W / 42.7792°N 96.9317°W / 42.7792; -96.9317 (First National Bank Building of Vermillion)	Vermillion
16	Forest Avenue Historic District		October 18, 1979 (#79002400)	Forest Ave. and Lewis St. Boundary clarification (listed March 6, 2012, refnum 12000086): 15-322 Forest Ave., 205-221 Lewis St. 42°46′36″N 96°55′43″W / 42.7767°N 96.9286°W / 42.7767; -96.9286 (Forest Avenue Historic District)	Vermillion
17	Garfield Township Hall		January 28, 2004 (#03001523)	16667 306th St. 42°57′08″N 96°51′50″W / 42.952222°N 96.863889°W / 42.952222; -96.863889 (Garfield Township Hall)	Beresford
18	Gunderson House		February 9, 2001 (#01000092)	24 S. Harvard 42°46′38″N 96°55′39″W / 42.7772°N 96.9275°W / 42.7772; -96.9275 (Gunderson House)	Vermillion
19	Inman House	More images	May 24, 1976 (#76001723)	415 E. Main St. 42°46′45″N 96°55′31″W / 42.7792°N 96.9253°W / 42.7792; -96.9253 (Inman House)	Vermillion
20	Basil H. & Frances Jacobson House	Upload image	November 17, 2022 (#100008376)	1101 James St. 42°47′24″N 96°57′17″W / 42.7901°N 96.9546°W / 42.7901; -96.9546 (Basil H. & Frances Jacobson House)	Vermillion
21	Calle Nissen Johnsen Farm	More images	December 17, 1999 (#99001581)	31494 453rd Ave. 42°49′26″N 97°08′24″W / 42.823815°N 97.139907°W / 42.823815; -97.139907 (Calle Nissen Johnsen Farm)	Gayville
22	Jolley Historic District	Upload image	November 17, 2022 (#100008377)	Roughly bounded by East Main, South Pine, East Lewis, East Canby, and South Harvard St. 42°46′33″N 96°55′27″W / 42.7759°N 96.9243°W / 42.7759; -96.9243 (Jolley Historic District)	Vermillion
23	Jens N. and Anna Junker Farmstead	More images	December 20, 1988 (#88002841)	Norway Township, Section 6 42°48′46″N 97°08′57″W / 42.812778°N 97.149167°W / 42.812778; -97.149167 (Jens N. and Anna Junker Farmstead)	Norway Township
24	Lincoln School No. 12	More images	August 16, 2000 (#00000995)	45352 Timber Rd. 42°47′39″N 97°07′50″W / 42.794104°N 97.130586°W / 42.794104; -97.130586 (Lincoln School No. 12)	Meckling
25	Linden House		September 14, 2001 (#01001001)	509 Linden Ave. 42°46′26″N 96°55′24″W / 42.7739°N 96.9233°W / 42.7739; -96.9233 (Linden House)	Vermillion
26	Daniel A. Messler Homestead	Upload image	February 14, 2002 (#02000022)	30337 Greenfield Rd. 42°59′36″N 96°50′59″W / 42.993333°N 96.849722°W / 42.993333; -96.849722 (Daniel A. Messler Homestead)	Beresford
27	Old Armory-Vermillion	More images	October 31, 2002 (#02001285)	414 E. Clark St. 42°47′03″N 96°55′31″W / 42.784186°N 96.925224°W / 42.784186; -96.925224 (Old Armory-Vermillion)	Vermillion	Now the Belbas Center on the campus of the University of South Dakota.
28	Old Main	More images	March 24, 1973 (#73001738)	Clark St. on the University of South Dakota campus 42°47′02″N 96°55′26″W / 42.7839°N 96.9239°W / 42.7839; -96.9239 (Old Main)	Vermillion
29	Prentis Park		November 8, 2001 (#01001218)	Plum and Main Sts. 42°46′53″N 96°55′05″W / 42.7814°N 96.9181°W / 42.7814; -96.9181 (Prentis Park)	Vermillion
30	Rice Farm	Upload image	January 20, 1978 (#78002544)	West of Vermillion 42°53′47″N 97°01′11″W / 42.896389°N 97.019722°W / 42.896389; -97.019722 (Rice Farm)	Vermillion
31	St. Agnes Catholic Church		March 27, 1995 (#95000280)	202 Washington St. 42°46′54″N 96°56′04″W / 42.7817°N 96.9344°W / 42.7817; -96.9344 (St. Agnes Catholic Church)	Vermillion	Now an arts center.
32	Sample-Lindblaum House	More images	December 2, 1998 (#98001405)	410 Idaho St. 43°00′15″N 97°06′29″W / 43.004062°N 97.108065°W / 43.004062; -97.108065 (Sample-Lindblaum House)	Wakonda
33	South Dakota Department of Trans. Br. No. 14-130-176	More images	November 8, 2001 (#01001220)	Local road over the Vermillion River 42°49′47″N 96°54′16″W / 42.829703°N 96.904550°W / 42.829703; -96.904550 (South Dakota Department of Trans. Br. No. 14-130-176)	Vermillion
34	South Dakota Department of Trans. Br. No. 14-133-170	More images	November 8, 2001 (#01001222)	Local road over the Vermillion River 42°50′14″N 96°53′44″W / 42.837295°N 96.895637°W / 42.837295; -96.895637 (South Dakota Department of Trans. Br. No. 14-133-170)	Vermillion
35	South Dakota Department of Transportation Bridge No. 14-060-032	More images	January 28, 2000 (#00000020)	Local road over Spring Creek 43°02′19″N 97°02′32″W / 43.038497°N 97.042220°W / 43.038497; -97.042220 (South Dakota Department of Transportation Bridge No. 14-060-032)	Wakonda	Apparently no longer extant[6]
36	South Dakota Department of Transportation Bridge No. 14-088-170	More images	January 14, 2000 (#99001689)	Local road over Clay Creek Ditch 42°50′14″N 96°59′19″W / 42.837289°N 96.988497°W / 42.837289; -96.988497 (South Dakota Department of Transportation Bridge No. 14-088-170)	Vermillion
37	South Dakota Department of Transportation Bridge No. 14-090-042	Upload image	January 14, 2000 (#99001700)	Local road over the Vermillion River 43°01′23″N 96°58′58″W / 43.0229804°N 96.9827101°W / 43.0229804; -96.9827101 (South Dakota Department of Transportation Bridge No. 14-090-042)	Wakonda
38	Spirit Mound	More images	November 19, 1974 (#74001889)	North of Vermillion 42°52′32″N 96°57′32″W / 42.8756°N 96.9589°W / 42.8756; -96.9589 (Spirit Mound)	Vermillion
39	University Historic District		February 24, 1975 (#75001714)	Bounded by N. Yale, E. Clark, Willow, and E. Main Sts. 42°46′52″N 96°55′27″W / 42.7811°N 96.9242°W / 42.7811; -96.9242 (University Historic District)	Vermillion	Named "Vermillion Historic District" until September 1, 2015
40	Vermillion-Andrew Carnegie Library		August 18, 1983 (#83003006)	12 Church St. 42°46′43″N 96°55′49″W / 42.7786°N 96.9303°W / 42.7786; -96.9303 (Vermillion-Andrew Carnegie Library)	Vermillion
41	Wakonda State Bank	More images	August 15, 2003 (#03000765)	118 Ohio St. 43°00′31″N 97°06′26″W / 43.008499°N 97.107291°W / 43.008499; -97.107291 (Wakonda State Bank)	Wakonda
42	E.H. Willey House		June 17, 1982 (#82003922)	104 Court St. 42°46′41″N 96°55′54″W / 42.7781°N 96.9317°W / 42.7781; -96.9317 (E.H. Willey House)	Vermillion
43	Yusten House	Upload image	January 23, 2007 (#06001310)	30831 Highway 19 42°55′20″N 96°57′17″W / 42.922222°N 96.954722°W / 42.922222; -96.954722 (Yusten House)	Vermillion

Former listings