This is a list of the National Register of Historic Places listings in Houston County, Alabama.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in Houston County, Alabama, United States. Latitude and longitude coordinates are provided for many National Register properties and districts; these locations may be seen together in an online map.^[1]

There are 10 properties and districts listed on the National Register in the county.

          This National Park Service list is complete through NPS recent listings posted February 2, 2024.^[2]

[3]	Name on the Register	Image	Date listed[4]	Location	City or town	Description
1	Alabama Midland Railway Depot		September 12, 1985 (#85002163)	Midland St. 31°10′58″N 85°14′15″W / 31.182778°N 85.2375°W / 31.182778; -85.2375 (Alabama Midland Railway Depot)	Ashford
2	Atlantic Coastline Railroad Passenger Depot		January 21, 1994 (#93001519)	Junction of Powell St. and Headland Ave. 31°13′50″N 85°23′30″W / 31.230556°N 85.391667°W / 31.230556; -85.391667 (Atlantic Coastline Railroad Passenger Depot)	Dothan
3	Dothan Municipal Light and Water Plant		October 3, 1991 (#90001315)	126 N. College St. 31°13′28″N 85°23′20″W / 31.224444°N 85.388889°W / 31.224444; -85.388889 (Dothan Municipal Light and Water Plant)	Dothan
4	Dothan Opera House	More images	December 16, 1977 (#77000204)	103 N. St. Andrews St. 31°13′26″N 85°23′29″W / 31.223889°N 85.391389°W / 31.223889; -85.391389 (Dothan Opera House)	Dothan
5	Federal Building and U.S. Courthouse	More images	December 31, 1974 (#74000412)	100 W. Troy St. 31°13′31″N 85°23′33″W / 31.225278°N 85.3925°W / 31.225278; -85.3925 (Federal Building and U.S. Courthouse)	Dothan
6	Howell School	Upload image	June 26, 2013 (#13000406)	408 E. Newton St. 31°13′43″N 85°23′18″W / 31.22853°N 85.38846°W / 31.22853; -85.38846 (Howell School)	Dothan
7	Main Street Commercial District		April 21, 1983 (#83002984)	E. Main, Foster, St. Andrews, Crawford, and Troy Sts.; also roughly bounded by Museum Ave., Crawford, Oates, Newton & College Sts. 31°13′24″N 85°23′31″W / 31.223333°N 85.391944°W / 31.223333; -85.391944 (Main Street Commercial District)	Dothan	Second set of addresses represents a boundary increase approved August 13, 2018.
8	Moody Hospital	Upload image	December 2, 2021 (#100007191)	311 North Alice St. 31°13′38″N 85°23′50″W / 31.2272°N 85.3973°W / 31.2272; -85.3973 (Moody Hospital)	Dothan
9	Purcell-Killingsworth House		December 16, 1982 (#82001616)	Main St. 31°17′49″N 85°06′40″W / 31.296944°N 85.111111°W / 31.296944; -85.111111 (Purcell-Killingsworth House)	Columbia	This Victorian mansion, also known as "Traveler's Rest", was completed in 1890.
10	Water Works Standpipe		December 13, 2016 (#16000835)	Intersection of East Powell and North Saint Andrews St., .5 mi. north of Main St. 31°13′49″N 85°23′31″W / 31.230293°N 85.391863°W / 31.230293; -85.391863 (Water Works Standpipe)	Dothan