This is a list of the National Register of Historic Places listings in Knox County, Indiana.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in Knox County, Indiana, United States. Latitude and longitude coordinates are provided for many National Register properties and districts; these locations may be seen together in a map.^[1]

There are 21 properties and districts listed on the National Register in the county, including 1 National Historic Landmark. Another 2 properties were once listed but have been removed.

Properties and districts located in incorporated areas display the name of the municipality, while properties and districts in unincorporated areas display the name of their civil township. Properties and districts split between multiple jurisdictions display the names of all jurisdictions.

          This National Park Service list is complete through NPS recent listings posted April 26, 2024.^[2]

Current listings

[3]	Name on the Register[4]	Image	Date listed[5]	Location	City or town	Description
1	County Bridge No. 45	More images	September 20, 2006 (#06000856)	Carries County Road 229 over the White River, northeast of Wheatland 38°40′46″N 87°16′23″W / 38.679444°N 87.273000°W / 38.679444; -87.273000 (County Bridge No. 45)	Steen Township	Extends into Daviess County
2	Enoco Coal Mine		December 28, 2010 (#10001100)	Northern side of Grundman Rd., 1.5 miles south of Bruceville 38°43′46″N 87°24′50″W / 38.729444°N 87.413889°W / 38.729444; -87.413889 (Enoco Coal Mine)	Washington Township
3	Fort Knox II Site		March 24, 1982 (#82000045)	3 miles north of downtown Vincennes[6] 38°43′27″N 87°30′24″W / 38.724167°N 87.506667°W / 38.724167; -87.506667 (Fort Knox II Site)	Vincennes
4	George Rogers Clark National Historical Park	More images	October 15, 1966 (#66000007)	401 S. 2nd St., south of U.S. Route 50 38°40′44″N 87°32′07″W / 38.678889°N 87.535278°W / 38.678889; -87.535278 (George Rogers Clark National Historical Park)	Vincennes
5	Gregg Park		September 25, 2013 (#13000756)	2204 Washington Ave. 38°41′06″N 87°30′08″W / 38.685000°N 87.502222°W / 38.685000; -87.502222 (Gregg Park)	Vincennes
6	Hack and Simon Office Building	More images	March 26, 2003 (#03000141)	1101 N. 3rd St. 38°41′04″N 87°31′14″W / 38.684444°N 87.520694°W / 38.684444; -87.520694 (Hack and Simon Office Building)	Vincennes
7	William Henry Harrison Home	More images	October 15, 1966 (#66000018)	3 W. Scott St. 38°41′08″N 87°31′34″W / 38.685556°N 87.526111°W / 38.685556; -87.526111 (William Henry Harrison Home)	Vincennes
8	Kimmell Park		September 25, 2013 (#13000757)	2014 Oliphant Dr. 38°41′48″N 87°31′04″W / 38.696667°N 87.517778°W / 38.696667; -87.517778 (Kimmell Park)	Vincennes
9	Kixmiller's Store	More images	December 8, 1978 (#78000035)	Carlise and Indianapolis Sts. at Freelandville 38°51′54″N 87°18′21″W / 38.865000°N 87.305833°W / 38.865000; -87.305833 (Kixmiller's Store)	Widner Township
10	Knox County Poor Asylum	Upload image	December 3, 2018 (#100003183)	2008 S. Hart Street Rd. 38°38′48″N 87°29′14″W / 38.646667°N 87.487222°W / 38.646667; -87.487222 (Knox County Poor Asylum)	Palmyra Township
11	Mont Clair	Upload image	December 27, 2016 (#16000904)	3890 E. Johnson Farm Rd. 38°39′33″N 87°28′11″W / 38.659100°N 87.469811°W / 38.659100; -87.469811 (Mont Clair)	Vincennes Township
12	Andrew Nicholson Farmstead		June 17, 2005 (#05000606)	12095 E. State Road 550, northwest of Wheatland 38°40′08″N 87°19′00″W / 38.668889°N 87.316667°W / 38.668889; -87.316667 (Andrew Nicholson Farmstead)	Steen Township
13	Old Cathedral Complex	More images	August 17, 1976 (#76000025)	205 Church St. 38°40′44″N 87°32′03″W / 38.678889°N 87.534167°W / 38.678889; -87.534167 (Old Cathedral Complex)	Vincennes
14	Old State Bank	More images	October 9, 1974 (#74000021)	N. 2nd St. 38°40′50″N 87°31′52″W / 38.680667°N 87.531111°W / 38.680667; -87.531111 (Old State Bank)	Vincennes
15	Pyramid Mound (12k14)	More images	May 12, 1975 (#75000023)	Southern side of Wabash Avenue, southeast of central Vincennes[7] 38°40′14″N 87°30′22″W / 38.670556°N 87.506111°W / 38.670556; -87.506111 (Pyramid Mound (12k14))	Vincennes	Also known as "Lower Sugarloaf Mound"[8]
16	Shadowwood		June 6, 2001 (#01000618)	6451 E. Wheatland Rd., east of Vincennes 38°41′59″N 87°25′06″W / 38.699722°N 87.418333°W / 38.699722; -87.418333 (Shadowwood)	Palmyra Township
17	Alfred Simonson House		December 24, 2009 (#09001131)	207 Shipping St. 38°48′43″N 87°14′55″W / 38.811806°N 87.248667°W / 38.811806; -87.248667 (Alfred Simonson House)	Edwardsport
18	Simpson Nursery Historic District	Upload image	May 24, 2021 (#100006564)	1502, 1504, 1512 Old Wheatland Rd. 38°41′14″N 87°28′41″W / 38.6872°N 87.4781°W / 38.6872; -87.4781 (Simpson Nursery Historic District)	Vincennes vicinity
19	Territorial Capitol of Former Indiana Territory	More images	July 2, 1973 (#73000021)	Bounded by Harrison, 1st, Scott, and Park Sts. 38°41′07″N 87°31′31″W / 38.685389°N 87.525167°W / 38.685389; -87.525167 (Territorial Capitol of Former Indiana Territory)	Vincennes
20	Vincennes Fortnightly Club		September 22, 2000 (#00001133)	421 N. 6th St. 38°40′45″N 87°31′31″W / 38.679167°N 87.525278°W / 38.679167; -87.525278 (Vincennes Fortnightly Club)	Vincennes
21	Vincennes Historic District		December 31, 1974 (#74000022)	Vincennes 38°40′41″N 87°31′43″W / 38.678056°N 87.528611°W / 38.678056; -87.528611 (Vincennes Historic District)	Vincennes

Former listings

[3]	Name on the Register	Image	Date listed	Date removed	Location	City or town	Description
1	Ebner-Free House	Upload image	March 21, 1985 (#85000601)	June 2, 1999	120 Locust	Vincennes	Moved to a new location in 1999
2	Rose Hill Farmstead		March 3, 1995 (#95000202)	June 15, 2012	Old Louisville Rd, 0.25 miles north of its junction with Old Wheatland Rd., and east of Vincennes 38°42′01″N 87°25′11″W / 38.700278°N 87.419722°W / 38.700278; -87.419722 (Rose Hill Farmstead)	Palmyra Township	Demolished in 2011