This is a list of the National Register of Historic Places listings in Pike County, Missouri.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in Pike County, Missouri, United States. Latitude and longitude coordinates are provided for many National Register properties and districts; these locations may be seen together in a map.^[1]

There are 21 properties and districts listed on the National Register in the county, including 1 National Historic Landmark.

          This National Park Service list is complete through NPS recent listings posted March 8, 2024.^[2]

Current listings

[3]	Name on the Register	Image	Date listed[4]	Location	City or town	Description
1	Charles Bacon House		July 19, 1990 (#90001104)	819 Kentucky St. 39°26′57″N 91°03′13″W / 39.449167°N 91.053611°W / 39.449167; -91.053611 (Charles Bacon House)	Louisiana
2	Capt. George and Attella Barnard House		March 31, 2000 (#00000309)	2009/2109 Georgia St. 39°26′32″N 91°03′53″W / 39.442222°N 91.064722°W / 39.442222; -91.064722 (Capt. George and Attella Barnard House)	Louisiana
3	Bethel Chapel AME Church	More images	July 28, 1995 (#95000926)	Junction of 6th and Tennessee Sts. 39°26′58″N 91°03′02″W / 39.449444°N 91.050556°W / 39.449444; -91.050556 (Bethel Chapel AME Church)	Louisiana
4	City Market		March 23, 2005 (#05000203)	125 S. Main St. 39°27′06″N 91°02′46″W / 39.451667°N 91.046111°W / 39.451667; -91.046111 (City Market)	Louisiana
5	James Beauchamp Clark House		December 8, 1976 (#76001114)	204 E. Champ Clark Dr. 39°20′29″N 91°11′27″W / 39.341389°N 91.190833°W / 39.341389; -91.190833 (James Beauchamp Clark House)	Bowling Green
6	Clarksville Historic District	More images	May 9, 1991 (#91000489)	Roughly bounded by Lewis, Front, Virginia and 3rd Sts. 39°22′11″N 90°54′16″W / 39.369722°N 90.904444°W / 39.369722; -90.904444 (Clarksville Historic District)	Clarksville
7	Clifford-Wyrick House		July 9, 1984 (#84002600)	105 S. 2nd St. 39°22′13″N 90°54′18″W / 39.370278°N 90.905°W / 39.370278; -90.905 (Clifford-Wyrick House)	Clarksville
8	Georgia Street Historic District	More images	May 6, 1987 (#87000653)	Roughly Georgia St. between Main and Seventh Sts. 39°26′57″N 91°02′56″W / 39.449167°N 91.048889°W / 39.449167; -91.048889 (Georgia Street Historic District)	Louisiana
9	Goodman-Stark House		October 22, 1994 (#94001205)	601 N. Third St. 39°27′14″N 91°03′00″W / 39.453889°N 91.05°W / 39.453889; -91.05 (Goodman-Stark House)	Louisiana
10	Griffith-McCune Farmstead Historic District		August 18, 1992 (#92001001)	MO WW E of junction with MO D 39°17′20″N 90°58′17″W / 39.288889°N 90.971389°W / 39.288889; -90.971389 (Griffith-McCune Farmstead Historic District)	Eolia
11	Lock and Dam No. 24 Historic District	More images	March 10, 2004 (#04000183)	350 N. 1st St. 39°22′36″N 90°54′30″W / 39.376667°N 90.908333°W / 39.376667; -90.908333 (Lock and Dam No. 24 Historic District)	Clarksville
12	Louisiana Chicago & Alton Railroad Depot	More images	June 7, 2006 (#06000472)	801 S. Third St. 39°26′49″N 91°02′38″W / 39.446944°N 91.043889°W / 39.446944; -91.043889 (Louisiana Chicago & Alton Railroad Depot)	Louisiana
13	Louisiana Public Library		April 12, 1996 (#96000401)	121 N. 3rd St. 39°27′02″N 91°02′51″W / 39.450556°N 91.0475°W / 39.450556; -91.0475 (Louisiana Public Library)	Louisiana
14	Luce-Dyer House	More images	September 23, 1982 (#82003157)	220 N. 3rd St. 39°27′04″N 91°02′54″W / 39.451111°N 91.048333°W / 39.451111; -91.048333 (Luce-Dyer House)	Louisiana
15	Meloan, Cummins & Co., General Store		June 24, 1993 (#93000571)	Junction of Middle and Water Sts., NW corner 39°15′45″N 90°54′02″W / 39.2625°N 90.900556°W / 39.2625; -90.900556 (Meloan, Cummins & Co., General Store)	Paynesville
16	North Third Street Historic District		August 24, 2005 (#05000912)	Roughly bounded by Georgia, Noyes, North Third and North Water Sts. 39°27′14″N 91°02′56″W / 39.453889°N 91.048889°W / 39.453889; -91.048889 (North Third Street Historic District)	Louisiana
17	Northern Methodist Episcopal Church of Clarksville		May 9, 1991 (#91000487)	309 Smith St. 39°22′03″N 90°54′14″W / 39.3675°N 90.903889°W / 39.3675; -90.903889 (Northern Methodist Episcopal Church of Clarksville)	Clarksville
18	Pike County Hospital		September 19, 2006 (#06000862)	2407 West Georgia St. 39°26′32″N 91°03′52″W / 39.442222°N 91.064444°W / 39.442222; -91.064444 (Pike County Hospital)	Louisiana
19	St. John's Episcopal Church	More images	July 8, 1970 (#70000346)	0.25 miles N of Eolia on CR D, 0.25 miles E on CR H 39°14′58″N 91°00′29″W / 39.249444°N 91.008056°W / 39.249444; -91.008056 (St. John's Episcopal Church)	Eolia
20	Gov. Lloyd Crow Stark House and Carriage House		December 21, 1987 (#87002142)	1401 Georgia St. 39°26′40″N 91°03′30″W / 39.444444°N 91.058333°W / 39.444444; -91.058333 (Gov. Lloyd Crow Stark House and Carriage House)	Louisiana
21	Turner-Pharr House		May 9, 1991 (#91000488)	101 N. Fourth St. 39°22′11″N 90°54′25″W / 39.369722°N 90.906944°W / 39.369722; -90.906944 (Turner-Pharr House)	Clarksville