This is a list of the National Register of Historic Places listings in St. Lucie County, Florida.

This is intended to be a complete list of the properties and districts on the National Register of Historic Places in St. Lucie County, Florida, United States. The locations of National Register properties and districts for which the latitude and longitude coordinates are included below, may be seen in a map.^[1]

There are 16 properties and districts listed on the National Register in the county, including 1 National Historic Landmark.

          This National Park Service list is complete through NPS recent listings posted March 8, 2024.^[2]

Current listings

[3]	Name on the Register[4]	Image	Date listed[5]	Location	City or town	Description
1	Arcade Building	More images	October 12, 2001 (#01001085)	101 U.S. Route 1, North 27°26′49″N 80°19′37″W / 27.446944°N 80.326944°W / 27.446944; -80.326944 (Arcade Building)	Fort Pierce
2	Casa Caprona	More images	June 2, 1984 (#84000955)	2605 St. Lucie Boulevard 27°28′59″N 80°21′06″W / 27.483056°N 80.351667°W / 27.483056; -80.351667 (Casa Caprona)	Fort Pierce
3	Cresthaven	More images	April 11, 1985 (#85000770)	239 South Indian River Drive (CR 707) 27°26′44″N 80°19′25″W / 27.445556°N 80.323611°W / 27.445556; -80.323611 (Cresthaven)	Fort Pierce
4	Fort Pierce Old Post Office	More images	February 11, 2002 (#01000567)	500 Orange Avenue 27°26′49″N 80°19′39″W / 27.446944°N 80.3275°W / 27.446944; -80.3275 (Fort Pierce Old Post Office)	Fort Pierce
5	Fort Pierce Site	More images	January 11, 1974 (#74002181)	South Indian River Drive 27°26′11″N 80°19′14″W / 27.436389°N 80.320556°W / 27.436389; -80.320556 (Fort Pierce Site)	Fort Pierce
6	Jules Frere House	More images	April 20, 1995 (#95000467)	2404 Sunrise Boulevard 27°25′27″N 80°20′06″W / 27.424167°N 80.335°W / 27.424167; -80.335 (Jules Frere House)	Fort Pierce
7	Captain Hammond House		February 23, 1990 (#90000310)	5775 Citrus Avenue 27°21′49″N 80°20′34″W / 27.363611°N 80.342778°W / 27.363611; -80.342778 (Captain Hammond House)	White City
8	Zora Neale Hurston House	More images	December 4, 1991 (#91002047)	1734 School Court 27°27′38″N 80°20′37″W / 27.460556°N 80.343611°W / 27.460556; -80.343611 (Zora Neale Hurston House)	Fort Pierce
9	Immokolee	More images	July 29, 1994 (#93001450)	8431 Immokolee Road 27°28′53″N 80°24′35″W / 27.481389°N 80.409722°W / 27.481389; -80.409722 (Immokolee)	Fort Pierce
10	Moores Creek Bridge	More images	August 17, 2001 (#01000890)	North 2nd Street between Avenues B and C 27°27′02″N 80°19′32″W / 27.450556°N 80.325556°W / 27.450556; -80.325556 (Moores Creek Bridge)	Fort Pierce
11	Old Fort Pierce City Hall	More images	December 7, 2001 (#01001338)	315 Avenue A 27°26′52″N 80°19′35″W / 27.447778°N 80.326389°W / 27.447778; -80.326389 (Old Fort Pierce City Hall)	Fort Pierce
12	Old St. Anastasia Catholic School	More images	August 10, 2000 (#00000941)	910 Orange Avenue 27°26′49″N 80°19′59″W / 27.446944°N 80.333056°W / 27.446944; -80.333056 (Old St. Anastasia Catholic School)	Fort Pierce
13	St. Lucie High School	More images	January 26, 1984 (#84000956)	1100 Delaware Avenue 27°26′36″N 80°20′01″W / 27.443333°N 80.333611°W / 27.443333; -80.333611 (St. Lucie High School)	Fort Pierce
14	St. Lucie Village Historic District	More images	December 1, 1989 (#89002062)	2505-3305 North Indian River Drive 27°29′17″N 80°20′10″W / 27.488056°N 80.336111°W / 27.488056; -80.336111 (St. Lucie Village Historic District)	St. Lucie Village
15	Sunrise Theatre	More images	December 7, 2001 (#01001339)	117 South 2nd Street 27°26′46″N 80°19′26″W / 27.446111°N 80.323889°W / 27.446111; -80.323889 (Sunrise Theatre)	Fort Pierce
16	URCA DE LIMA (shipwreck)	Upload image	May 31, 2001 (#01000529)	200 yards offshore of Jack Island Park, north of Ft. Pierce Inlet 27°30′11″N 80°17′54″W / 27.503056°N 80.298333°W / 27.503056; -80.298333 (URCA DE LIMA (shipwreck))	Fort Pierce