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Names | |
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IUPAC name
3-(1-methylpyrrol-2-yl)pyridine
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Other names
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.006.956 |
EC Number |
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KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C10H10N2 | |
Molar mass | 158.204 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Nicotryine is lesser known and minor tobacco alkaloid. It inhibits metabolism of nicotine[2][3] through CYP2A6 enzyme inhibition (Ki = 7.5 ± 2.9).[2][4][5] It also inhibits CYP2A13 (Ki = 5.6 ± 0.86) which might play role in nicotine metabolism.[5][6] Nicotyrine is formed by gradual oxidation of nicotine in e-liquids and causes delayed nicotine clearance and attenuated withdrawal symptoms.[6]
It has insecticidal properties like nicotine and certain derivatives have been synthesized for that property.[7]
alpha-nicotyrine and beta-nicotyrine are positional isomers of each other.
Nicotyrine can be produced readily from nicotine by catalytic dehydrogenation[8] and from tobacco biomass by catalytic pyrolysis.[9]