Nifuratel
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 5-[(Methylthio)methyl]-3-{[(1E)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ECHA InfoCard100.023.251 Edit this at Wikidata
Chemical and physical data
FormulaC10H11N3O5S
Molar mass285.27 g·mol−1
3D model (JSmol)
  • CSCC1CN(C(=O)O1)/N=C/C2=CC=C(O2)[N+](=O)[O-]
  • InChI=1S/C10H11N3O5S/c1-19-6-8-5-12(10(14)18-8)11-4-7-2-3-9(17-7)13(15)16/h2-4,8H,5-6H2,1H3/b11-4+
  • Key:SRQKTCXJCCHINN-NYYWCZLTSA-N
  (verify)

Nifuratel (brand name Macmiror, or — in combination with nystatin, — Macmiror Complex) is a drug used in gynecology. It is a local antiprotozoal and antifungal agent that may also be given orally. Nifuratel is not approved for use in the United States.

Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp.[1]

Taken orally, or as a vaginal pessary, it is used in the treatment of a wide range of infections of the genito-urinary tract, especially if there is no accurate diagnosis available. For example, it may be used in the treatment of women exhibiting vaginal discharge where there is uncertainty as to whether the cause is Trichomonas vaginalis or Candida strains such as Candida albicans.

Side effects appear to be minimal or non-existent and it has a safe toxicological profile.[2]

References

  1. ^ Grüneberg RN, Leakey A (October 1976). "Treatment of candidal urinary tract infection with nifuratel". British Medical Journal. 2 (6041): 908–10. doi:10.1136/bmj.2.6041.908. PMC 1688487. PMID 974657.
  2. ^ Mendling W, Mailland F (2002). "Microbiological and pharmaco-toxicological profile of nifuratel and its favourable risk/benefit ratio for the treatment of vulvo-vaginal infections. A review". Arzneimittel-Forschung. 52 (1): 8–13. doi:10.1055/s-0031-1299849. PMID 11838277.
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