Noradrenergic cell group A5
Details
Identifiers
Latincellulae noradrenergicae pontis caudalis lateralis [A5]
TA98A14.1.09.606
FMA71966
Anatomical terminology

Noradrenergic cell group A5 is a group of cells in the vicinity of the superior olivary complex in the pontine tegmentum that label for norepinephrine in primates,[1] rodents[2] and other mammals.[3] The noradrenergic A5 pontine cell group receives inputs from the hypothalamus and several brainstem areas extending from the midbrain to the medulla. It has reciprocal connections with these areas. Its major output is to the spinal cord.[4][5][6] These anatomical connections suggest a role in autonomic regulation and A5 has been implicated in control of heart rate, blood pressure and respiration.[7][8][9][10][11] It may also be involved in modulation of pain as part of the descending mesencephalic to spinal cord system.[12]

References

  1. ^ Felten DL, Sladek JR Jr (1983). "Monoamine distribution in primate brain V. Monoaminergic nuclei: anatomy, pathways and local organization". Brain Research Bulletin. 10 (2): 171–284. doi:10.1016/0361-9230(83)90045-x. PMID 6839182. S2CID 13176814.
  2. ^ Dahlstrom A, Fuxe K (1964). "Evidence for the existence of monoamine-containing neurons in the central nervous system". Acta Physiologica Scandinavica. 62: 1–55. PMID 14229500.
  3. ^ Kitahama K, Nagatsu I, Pearson J (1994). Catecholamine systems in mammalian midbrain and hindbrain: theme and variations. Chapter 8 in Phylogeny and Development of Catecholamine Systems in the CNS of Vertebrates, Smeets WJAJ and Reiner A (eds). Cambridge, England: University Press.
  4. ^ Byrum, C.E. and Guyenet, P.G., 1987. Afferent and efferent connections of the A5 noradrenergic cell group in the rat. Journal of Comparative Neurology, 261(4), pp.529-542
  5. ^ Woodruff, Michael L., Ronald H. Baisden, Dennis L. Whittington, and Joseph E. Kelly. "Inputs to the pontine A5 noradrenergic cell group: a horseradish peroxidase study." Experimental neurology 94, no. 3 (1986): 782-787
  6. ^ Blessing, W. W., A. Ko Goodchild, R. A. L. Dampney, and J. Po Chalmers. "Cell groups in the lower brain stem of the rabbit projecting to the spinal cord, with special reference to catecholamine-containing neurons." Brain research 221, no. 1 (1981): 35-55
  7. ^ Andrade, Rodrigo, and George K. Aghajanian. "Single cell activity in the noradrenergic A-5 region: responses to drugs and peripheral manipulations of blood pressure." Brain Research 242, no. 1 (1982) 125-136.
  8. ^ Drye, Randall G., Ronald H. Baisden, Dennis L. Whittington, and Michael L. Woodruff. "The effects of stimulation of the A5 region on blood pressure and heart rate in rabbits." Brain research bulletin 24, no. 1 (1990) 33-39.
  9. ^ Guyenet, P. G., Koshiya, N., Huangfu, G., Verberne, A. J. and Riley, T. A. "Central respiratory control of A5 and A6 pontine noradrenergic neurons." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 264, no. 6 (1993): R1035-R1044
  10. ^ Taxini, Camila L., Thiago S. Moreira, Ana C. Takakura, Kênia C. Bícego, Luciane H. Gargaglioni, and Daniel B. Zoccal. "Role of A5 noradrenergic neurons in the chemoreflex control of respiratory and sympathetic activities in unanesthetized conditions." Neuroscience 354 (2017): 146-157.
  11. ^ Woodruff, Michael L., Ronald H. Baisden, and Dennis L. Whittington. "Effects of electrical stimulation of the pontine A5 cell group on blood pressure and heart rate in the rabbit." Brain research 379, no. 1 (1986): 10-23.
  12. ^ Pertovaara, Antti. "Noradrenergic pain modulation." Progress in neurobiology 80, no. 2 (2006): 53-83.

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