NUP107
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUP107, NUP84, NPHS11, nucleoporin 107kDa, nucleoporin 107, ODG6, ODG6; GAMOS7
External IDsOMIM: 607617 MGI: 2143854 HomoloGene: 5555 GeneCards: NUP107
Orthologs
SpeciesHumanMouse
Entrez

57122

103468

Ensembl

ENSG00000111581

ENSMUSG00000052798

UniProt

P57740

Q8BH74

RefSeq (mRNA)

NM_020401
NM_001330192

NM_134010

RefSeq (protein)

NP_001317121
NP_065134

NP_598771

Location (UCSC)Chr 12: 68.69 – 68.75 MbChr 10: 117.59 – 117.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.[5][6][7]

Function

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]

Interactions

NUP107 has been shown to interact with NUP133.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111581 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052798 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proceedings of the National Academy of Sciences of the United States of America. 100 (3): 981–5. Bibcode:2003PNAS..100..981B. doi:10.1073/pnas.252749899. PMC 298712. PMID 12552102.
  6. ^ Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell. 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. S2CID 16449133.
  7. ^ a b "Entrez Gene: NUP107 nucleoporin 107kDa".
  8. ^ Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
  9. ^ Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.

Further reading


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