OASL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WH3, 4XQ7
Identifiers
Aliases	OASL, OASLd, TRIP-14, TRIP14, p59 p59-p592'-5'-oligoadenylate synthetase like, OASL1
External IDs	OMIM: 603281 MGI: 2180849 HomoloGene: 2769 GeneCards: OASL
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 121,017,763 bp[1] End 121,039,242 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 115,061,299 bp[2] End 115,075,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood pancreatic ductal cell monocyte right lung right lobe of liver bone marrow upper lobe of left lung appendix body of stomach periodontal fiber Top expressed in pyloric antrum mucous cell of stomach intestinal villus epithelium of stomach duodenum jejunum ileum large intestine colon left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding thyroid hormone receptor binding 2'-5'-oligoadenylate synthetase activity double-stranded RNA binding ATP binding RNA binding Cellular component cytoplasm membrane nucleolus nucleus nucleoplasm cytosol Biological process immune system process interferon-gamma-mediated signaling pathway response to virus negative regulation of viral genome replication type I interferon signaling pathway immune response innate immune response defense response to virus regulation of ribonuclease activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8638 231655 Ensembl ENSG00000135114 ENSMUSG00000041827 UniProt Q15646 Q8VI94 RefSeq (mRNA) NM_198213 NM_001261825 NM_003733 NM_001395418 NM_001395419 NM_145209 NM_001359945 NM_001359946 RefSeq (protein) NP_001248754 NP_003724 NP_937856 NP_660210 NP_001346874 NP_001346875 Location (UCSC) Chr 12: 121.02 – 121.04 Mb Chr 5: 115.06 – 115.08 Mb PubMed search [3] [4]
Wikidata
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59 kDa 2'-5'-oligoadenylate synthetase-like protein is an enzyme that in humans is encoded by the OASL gene.^[5][6]

2'-5'-oligoadenylate synthase is a protein family of structurally similar proteins, including OAS1, OAS2, and OAS3. OASL, like the proteins of 2'-5'-oligoadenylate synthase family, is induced by interferons.