OR1A1
Identifiers
AliasesOR1A1, OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene)
External IDsOMIM: 618046 MGI: 1333770 HomoloGene: 8219 GeneCards: OR1A1
Orthologs
SpeciesHumanMouse
Entrez

8383

258706

Ensembl

ENSG00000172146

ENSMUSG00000070377

UniProt

Q9P1Q5

n/a

RefSeq (mRNA)

NM_014565
NM_001386104

NM_146711

RefSeq (protein)

NP_055380

n/a

Location (UCSC)Chr 17: 3.21 – 3.22 MbChr 11: 74.1 – 74.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

Ligands

OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules.[7][8] Examples of known ligands, most of which have citrus or fruity smells:[9][10]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172146 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070377 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
  6. ^ a b "Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1".
  7. ^ a b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
  8. ^ a b Block E, Batista VS, Matsunami H, Zhuang H, Ahmed L (May 2017). "The role of metals in mammalian olfaction of low molecular weight organosulfur compounds". Natural Product Reports. 34 (5): 529–557. doi:10.1039/c7np00016b. PMC 5542778. PMID 28471462.
  9. ^ a b c Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748.
  10. ^ Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


G protein-coupled receptors: olfactory receptors
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