OR1D2
Identifiers
AliasesOR1D2, OLFR1, OR17-4, olfactory receptor family 1 subfamily D member 2
External IDsOMIM: 164342 MGI: 3030246 HomoloGene: 37634 GeneCards: OR1D2
Orthologs
SpeciesHumanMouse
Entrez

4991

258153

Ensembl

n/a

ENSMUSG00000058275

UniProt

P34982

Q7TRW7

RefSeq (mRNA)

NM_002548
NM_001386088

NM_001011851

RefSeq (protein)

NP_002539

NP_001011851

Location (UCSC)n/aChr 11: 74.25 – 74.26 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.[4][5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

Expression

As well as bring expressed in the olfactory epithelium of the human nose, OR1D2 is special in that it is also expressed in human spermatozoa, where it is involved in sperm chemotaxis.[7]

Ligands

Bourgeonal is a reported ligand for OR1D2 that affects sperm chemotaxis.[7]

Ligands include:[7]

See also

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058275 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID 1370859. S2CID 43926.
  5. ^ Buck L, Axel R (May 1991). "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition". Cell. 65 (1): 175–87. doi:10.1016/0092-8674(91)90418-X. PMID 1840504.
  6. ^ a b "Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2".
  7. ^ a b c Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (March 2003). "Identification of a testicular odorant receptor mediating human sperm chemotaxis". Science. 299 (5615): 2054–8. Bibcode:2003Sci...299.2054S. doi:10.1126/science.1080376. PMID 12663925. S2CID 45306091.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



G protein-coupled receptors: olfactory receptors
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