OR2J3
Identifiers
AliasesOR2J3, 6M1-3, C3HEXS, HS6M1-3, OR6-16, OR6-6, OR6.3.6, ORL671, olfactory receptor family 2 subfamily J member 3
External IDsOMIM: 615016 HomoloGene: 128270 GeneCards: OR2J3
Orthologs
SpeciesHumanMouse
Entrez

442186

n/a

Ensembl

ENSG00000204701

n/a

UniProt

O76001

n/a

RefSeq (mRNA)

NM_001005216

n/a

RefSeq (protein)

NP_001005216

n/a

Location (UCSC)Chr 6: 29.11 – 29.11 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Olfactory receptor 2J3 is a protein that in humans is encoded by the OR2J3 gene.[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

Genetic variation

A pair of two single-nucleotide polymorphisms, both in the OR2J3 gene, strongly reduce sensitivity to the odorant cis-3-hexen-1-ol, which has a "cut grass" smell.[4]

Ligands

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204701 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: OR2J3 olfactory receptor, family 2, subfamily J, member 3".
  4. ^ a b McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H, Newcomb RD (September 2012). "Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol". Chemical Senses. 37 (7): 585–93. doi:10.1093/chemse/bjs049. PMC 3408771. PMID 22714804.
  5. ^ Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


G protein-coupled receptors: olfactory receptors
Categories