ORC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3M03
Identifiers
Aliases	ORC6, ORC6L, origin recognition complex subunit 6
External IDs	OMIM: 607213 MGI: 1929285 HomoloGene: 8635 GeneCards: ORC6
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q11.2 Start 46,689,643 bp[1] End 46,698,394 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 86,026,261 bp[2] End 86,034,907 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte endothelial cell secondary oocyte embryo ganglionic eminence spongy bone sperm bone marrow thymus bone marrow cells Top expressed in secondary oocyte otic placode maxillary prominence somite morula primitive streak endocardial cushion hand abdominal wall medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding DNA replication origin binding Cellular component nucleus membrane nucleoplasm origin recognition complex fibrillar center nuclear origin of replication recognition complex Biological process G1 phase DNA replication DNA replication initiation negative regulation of cell division G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23594 56452 Ensembl ENSG00000091651 ENSMUSG00000031697 UniProt Q9Y5N6 Q9WUJ8 RefSeq (mRNA) NM_014321 NM_001163791 NM_019716 RefSeq (protein) NP_055136 n/a Location (UCSC) Chr 16: 46.69 – 46.7 Mb Chr 8: 86.03 – 86.03 Mb PubMed search [3] [4]
Wikidata
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Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.^[5][6]

Background

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.

Function

The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and ORC1 are loosely associated with the core complex consisting of ORC2, -3, -4 and -5. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.^[6]

Interactions

ORC6 has been shown to interact with MCM5,^[7] ORC2,^[7][8] Replication protein A1,^[7] ORC4,^[7] DBF4,^[7] ORC3,^[7][8] CDC45-related protein,^[7] MCM4^[7] and Cell division cycle 7-related protein kinase.^[7]