In Greek mythology, Oizys (/ˈoʊɪzɪs/; Ancient Greek: Ὀϊζύς, romanized: Oïzús, lit. 'misery'^[1]), or Oezys, is the personification of pain or distress.^[2]

In Hesiod's Theogony, Oizys is one of the offspring of Nyx (Night), produced without the assistance of a father.^[3] According to the Roman authors Cicero and Hyginus, "Miseria" (Misery) is one of the offspring of the Nox (Night, the Roman equivalent of Nyx) and Erebus.^[4] Oizys has no distinct mythology of her own.