|Preferred IUPAC name
Oleic acid amide
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||281.484 g·mol−1|
|Melting point||70 °C (158 °F; 343 K)|
|Boiling point||> 200 °C (392 °F; 473 K)|
|NFPA 704 (fire diamond)|
|Flash point||> 200 °C (392 °F; 473 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
what is ?)(
Oleamide is an organic compound with the formula CH3(CH2)7CH=CH(CH2)7CONH2(. It is the amide derived from the fatty acid oleic acid. It is a colorless waxy solid and occurs in nature. Sometimes labeled as a fatty acid primary amide (FAPA), it is biosynthesized from N-oleoylglycine.
In terms of natural occurrence, oleamide was first detected in human plasma. It was later shown to accumulate in the cerebrospinal fluid during sleep deprivation and induces sleep in animals.
It has been considered as a potential treatment for mood and sleep disorders, as well as cannabinoid-regulated depression.
In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems.
Synthetic oleamide has a variety of industrial uses including as a slip agent, a lubricant, and a corrosion inhibitor.
Oleamide was found to be leaking out of polypropylene plastics in laboratory experiments, affecting experimental results. Since polypropylene is used in a wide number of food containers such as those for yogurt, the problem is being studied.
Oleamide is "one of the most frequent non-cannabinoid ingredients associated with Spice products." Analysis of 44 products synthetic cannabinoid revealed oleamide in 7 of the products tested.