Oliver Wendell Holmes may refer to:

People

• Oliver Wendell Holmes Sr. (1809–1894), poet, physician, and essayist, father of the judge
• Oliver Wendell Holmes Jr. (1841–1935), an associate justice of the Supreme Court of the United States, son of the essayist
• Oliver Wendell Holmes (archivist) (1902–1981), American archivist and historian
• Wendell Holmes (actor) (1914–1962), character actor Oliver Wendell Holmes

Schools

• Oliver Wendell Holmes Junior High School, Davis, California, named after Oliver Wendell Holmes Sr.
• Oliver Wendell Holmes High School, San Antonio, Texas named after Oliver Wendell Holmes Jr.