Olmesartan/hydrochlorothiazide
Combination of
OlmesartanAngiotensin II antagonist
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesBenicar HCT, Benitec H, others
AHFS/Drugs.comMicromedex Detailed Consumer Information
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG

Olmesartan/hydrochlorothiazide, sold under the brand name Benicar HCT among others, is a fixed-dose combination medication used to treat high blood pressure.[1][2] It is a combination of olmesartan medoxomil, an angiotensin II receptor blocker and hydrochlorothiazide, a diuretic.[2] It may be used if olmesartan is not sufficient to manage blood pressure.[3] It is taken by mouth.[3]

Common side effects include nausea, dizziness, and upper respiratory tract infections.[1] Serious side effects may include kidney problems, allergic reactions, electrolyte problems and low blood pressure.[1] Use in pregnancy is not recommended.[1] Olmesartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by increasing the loss of sodium by the kidneys.[1]

No generic version is available in the United States as of 2017.[2] In 2020, it was the 281st most commonly prescribed medication in the United States, with more than 1 million prescriptions.[4][5]

References

  1. ^ a b c d e f "Benicar HCT- olmesartan medoxomil-hydrochlorothiazide tablet, film coated". DailyMed. 7 September 2022. Retrieved 3 January 2023.
  2. ^ a b c Bope ET, Kellerman RD (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 9780323443357.
  3. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 177–178. ISBN 9780857113382.
  4. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  5. ^ "Hydrochlorothiazide; Olmesartan - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
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