Onofrio Palumbo (born 1606) (active 1650, Naples)^[1] was an Italian painter of the Baroque period.

In the church of the Santissima Trinità dei Pellegrini, Naples, he painted an altarpiece of San Gennaro protecting Naples from lightning. He also painted a contemporary portrait of Masaniello now at the museum of the Certosa di San Martino.