Otter Creek may refer to some places in the North America:

Bodies of water

• Otter Creek (British Columbia), a river in British Columbia
• Otter Creek (Delaware River), a tributary of the Delaware River, also known as Mill Creek
• Otter Creek (Ocmulgee River tributary), a stream in Georgia that connects to the Ocmulgee River
• Otter Creek (Seventeen Mile Creek tributary), a stream in Georgia
• Otter Creek (Wabash River), a stream in Indiana
• Otter Creek (Iowa River tributary), a river in Iowa
• Otter Creek (Pechman Creek tributary), a river in Iowa
• Otter Creek (Saint Louis River), a stream in Minnesota
• Otter Creek (Lamine River), a river in Missouri
• Otter Creek (North Fork Salt River), a river in Missouri
• Otter Creek (St. Francis River), a stream in Missouri
• Otter Creek (Niobrara River tributary), a stream in Holt and Rock Counties, Nebraska
• Otter Creek (Black River tributary), a stream in New York
• Otter Creek (Tennessee), a tributary of the Little Harpeth River
• Otter Creek (Vermont), a tributary of Lake Champlain
• Otter Creek (Wisconsin), a stream in Sauk County
• Otter Creek (Lake Erie), a watershed administered by the Long Point Region Conservation Authority, that drains into Lake Erie
• Otter Creek (Wyoming) , is a stream in Wyoming and has an elevation of 6,342 feet. Otter Creek is situated south of Spring Creek, and southwest of Lone Bear Ditch Number 2.

Cities and towns

• Otter Creek, Florida, a town
• Otter Creek, Georgia, an unincorporated community
• Otter Creek, Iowa, an unincorporated community
• Otter Creek, Kentucky, an unincorporated community
• Otter Creek, Minnesota, an unincorporated community near Cloquet, Minnesota
• Otter Creek, Dunn County, Wisconsin, a town
• Otter Creek, Eau Claire County, Wisconsin, a town

Other uses

• Otter Creek Outdoor Recreation Area, near Louisville, Kentucky
• Otter Creek Wilderness, a wilderness area in West Virginia
• Otter Creek Brewing, a brewery in Middlebury, Vermont