P2RX6
Identifiers
Aliases	P2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6
External IDs	OMIM: 608077 MGI: 1337113 HomoloGene: 3975 GeneCards: P2RX6
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 21,009,808 bp[1] End 21,028,013 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,379,749 bp[2] End 17,395,664 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle right uterine tube Brodmann area 9 spleen anterior pituitary prefrontal cortex right adrenal gland right coronary artery hypothalamus substantia nigra Top expressed in facial motor nucleus skeletal muscle tissue soleus muscle quadriceps femoris muscle morula temporal muscle masseter muscle anterior horn of spinal cord vastus lateralis muscle intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function channel activity purinergic nucleotide receptor activity extracellularly ATP-gated cation channel activity ion channel activity identical protein binding ATP binding transmembrane signaling receptor activity ATP-gated ion channel activity Cellular component cytoplasm integral component of membrane membrane integral component of nuclear inner membrane integral component of plasma membrane cell junction plasma membrane postsynapse postsynaptic density neuronal cell body dendritic spine parallel fiber to Purkinje cell synapse glutamatergic synapse integral component of postsynaptic specialization membrane Biological process response to ATP muscle contraction ion transport cation transmembrane transport protein homooligomerization signal transduction blood coagulation purinergic nucleotide receptor signaling pathway excitatory postsynaptic potential protein heterooligomerization cation transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9127 18440 Ensembl ENSG00000099957 ENSMUSG00000022758 UniProt O15547 O54803 RefSeq (mRNA) NM_001159554 NM_005446 NM_001349874 NM_001349875 NM_001349876 NM_001394691 NM_001394692 NM_001394693 NM_001394694 NM_001394695 NM_001394696 NM_001394697 NM_001159561 NM_011028 RefSeq (protein) NP_001153026 NP_005437 NP_001336803 NP_001336804 NP_001336805 NP_001153033 NP_035158 Location (UCSC) Chr 22: 21.01 – 21.03 Mb Chr 16: 17.38 – 17.4 Mb PubMed search [3] [4]
Wikidata
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P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.^[5][6][7][8]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.^[8]