P2RY6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6R
Identifiers
Aliases	P2RY6, P2Y6, pyrimidinergic receptor P2Y6
External IDs	OMIM: 602451 MGI: 2673874 HomoloGene: 14289 GeneCards: P2RY6
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 73,264,498 bp[1] End 73,305,103 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,586,837 bp[2] End 100,623,856 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen placenta right coronary artery left coronary artery appendix kidney thoracic aorta ascending aorta right lobe of thyroid gland striated muscle tissue Top expressed in ascending aorta aortic valve calvaria left colon ankle internal carotid artery subcutaneous adipose tissue dermis carotid body white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity protein binding G protein-coupled UDP receptor activity signal transducer activity G protein-coupled ADP receptor activity G protein-coupled UTP receptor activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane apical plasma membrane membrane Biological process positive regulation of smooth muscle cell migration phospholipase C-activating G protein-coupled receptor signaling pathway cellular response to organic cyclic compound transepithelial chloride transport signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway cellular response to prostaglandin E stimulus G protein-coupled receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of vascular associated smooth muscle cell proliferation phagocytosis activation of phospholipase C activity positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of inositol trisphosphate biosynthetic process cellular response to purine-containing compound cellular response to pyrimidine ribonucleotide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5031 233571 Ensembl ENSG00000171631 ENSMUSG00000048779 UniProt Q15077 Q9ERK9 RefSeq (mRNA) NM_001277204 NM_001277205 NM_001277206 NM_001277207 NM_001277208 NM_004154 NM_176796 NM_176797 NM_176798 NM_183168 RefSeq (protein) NP_001264133 NP_001264134 NP_001264135 NP_001264136 NP_001264137 NP_789766 NP_789767 NP_789768 NP_898991 Location (UCSC) Chr 11: 73.26 – 73.31 Mb Chr 7: 100.59 – 100.62 Mb PubMed search [3] [4]
Wikidata
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P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.^[5][6]

Function

The product of this gene, P2Y₆, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.^[6]