Protein-coding gene in the species Homo sapiens
PADI2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4N20, 4N22, 4N24, 4N25, 4N26, 4N28, 4N2A, 4N2B, 4N2C, 4N2D, 4N2E, 4N2F, 4N2G, 4N2H, 4N2I, 4N2K, 4N2L, 4N2M, 4N2N |
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Identifiers |
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Aliases | PADI2, PAD-H19, PAD2, PDI2, peptidyl arginine deiminase 2 |
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External IDs | OMIM: 607935 MGI: 1338892 HomoloGene: 7214 GeneCards: PADI2 |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - internal globus pallidus
- inferior olivary nucleus
- inferior ganglion of vagus nerve
- middle frontal gyrus
- external globus pallidus
- subthalamic nucleus
- gastrocnemius muscle
- tibialis anterior muscle
- optic nerve
- ventral tegmental area
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| Top expressed in | - saccule
- lacrimal gland
- digastric muscle
- retinal pigment epithelium
- sternocleidomastoid muscle
- stria vascularis
- triceps brachii muscle
- ankle
- vastus lateralis muscle
- utricle
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| More reference expression data |
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BioGPS | |
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Wikidata |
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Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene.[5][6]
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages.
This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.[6]