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The Platform Adaptive Trial of Novel Antivirals for Early Treatment of COVID-19 in the Community (PANORAMIC Trial) is a clinical trial in the United Kingdom to test the effectiveness of new antiviral drugs at the early stages of COVID-19 infections.[1][2][3] The study aims to find out if antivirals can prevent the need for hospitalisation and help faster recovery for people aged over 50 and those at higher risk due to underlying health conditions.[4] PANORAMIC is sponsored by the University of Oxford and funded by the National Institute for Health and Care Research (NIHR).[5] The trial was launched in December 2021, and as of June 2022, over 25,000 people are enrolled as participants.[6]

Overview

PANORAMIC is a platform trial[7] that will compare two groups who are having symptoms of COVID: one will receive standard NHS care and the other one will receive standard NHS care plus antiviral treatment. Participants can take part from home online or via phone and the antivirals are delivered to them.[8]

Participants

People can enroll in the study if they had symptoms of COVID (confirmed by a test) less than 5 days prior to enrolling. They have to be either aged 50 or over, or have a preexisting health condition.[8][2]

Treatments

The antivirals tested in the study will be molnupiravir[7] and nirmatrelvir/ritonavir (Paxlovid).[9]

Results

Molnupiravir

In December 2022, results from the trial showed that for higher risk, vaccinated adults molnupiravir does not reduce the chances of hospitalisation and death. However it leads to faster recovery and reduced viral load.[10][11]

See also

References

  1. ^ "PANORAMIC". www.panoramictrial.org. Retrieved 16 March 2022.
  2. ^ a b "Thousands needed to try a new Covid antiviral treatment". BBC News. 25 January 2022. Retrieved 16 March 2022.
  3. ^ "Public urged to sign up to world-first COVID-19 antiviral study". GOV.UK. Retrieved 16 March 2022.
  4. ^ "Covid cost-cutting will put blinkers on our best Covid research". the Guardian. 21 February 2022. Retrieved 16 March 2022.
  5. ^ "NIHR funds community COVID-19 antiviral trial". www.nihr.ac.uk. Retrieved 16 March 2022.
  6. ^ Pinching, John (22 February 2022). "PANORAMIC view of World's largest COVID study". PharmaTimes. Retrieved 16 March 2022.
  7. ^ a b "Over ten thousand participants enrol in world's largest COVID-19 antiviral study". www.nihr.ac.uk. Retrieved 16 March 2022.
  8. ^ a b "Participant Information — PANORAMIC". www.panoramictrial.org. Retrieved 16 March 2022.
  9. ^ "Second ground-breaking antiviral to be deployed to country's most vulnerable". GOV.UK. Retrieved 16 March 2022.
  10. ^ Butler, Christopher C; Hobbs, F D Richard; Gbinigie, Oghenekome A; Rahman, Najib M; Hayward, Gail; Richards, Duncan B; Dorward, Jienchi; Lowe, David M; Standing, Joseph F; Breuer, Judith; Khoo, Saye; Petrou, Stavros; Hood, Kerenza; Nguyen-Van-Tam, Jonathan S; Patel, Mahendra G (22 December 2022). "Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial". The Lancet. 401 (10373): 281–293. doi:10.1016/S0140-6736(22)02597-1. PMC 9779781. PMID 36566761.
  11. ^ "Pill for Covid does not reduce risk of hospitalisation or death, UK study finds". the Guardian. 22 December 2022. Retrieved 29 December 2022.

External links

COVID-19 pandemic in the United Kingdom, Crown Dependencies and British Overseas Territories
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