CDK16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDK16, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1, cyclin-dependent kinase 16, cyclin dependent kinase 16
External IDsOMIM: 311550; MGI: 97516; HomoloGene: 7878; GeneCards: CDK16; OMA:CDK16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001170460
NM_006201
NM_033018
NM_033019

NM_011049
NM_001310456

RefSeq (protein)

NP_001163931
NP_006192
NP_148978

NP_001297385
NP_035179

Location (UCSC)Chr X: 47.22 – 47.23 MbChr X: 20.55 – 20.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the CDK16 gene.[5][6]

Function

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.[6]

Interactions

PCTK1 has been shown to interact with CDK5R1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102225Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031065Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.
  6. ^ a b "Entrez Gene: PCTK1 PCTAIRE protein kinase 1".
  7. ^ Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (Aug 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709.

Further reading