PDZK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1, PDZ domain containing 1
External IDsOMIM: 603831 MGI: 1928901 HomoloGene: 1964 GeneCards: PDZK1
Orthologs
SpeciesHumanMouse
Entrez

5174

59020

Ensembl

ENSG00000174827

ENSMUSG00000038298

UniProt

Q5T2W1

Q9JIL4

RefSeq (mRNA)

NM_001201325
NM_001201326
NM_002614

NM_001146001
NM_021517
NM_001355710

RefSeq (protein)

NP_001188254
NP_001188255
NP_002605
NP_001358288
NP_001358290

NP_001139473
NP_067492
NP_001342639

Location (UCSC)Chr 1: 145.67 – 145.71 MbChr 3: 96.74 – 96.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.[5][6]

Interactions

PDZK1 has been shown to interact with:

Related gene problems

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174827 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038298 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest. 78 (1): 117–25. PMID 9461128.
  6. ^ "Entrez Gene: PDZK1 PDZ domain containing 1".
  7. ^ a b c d e f g h Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
  8. ^ a b Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (February 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.
  9. ^ Wang S, Yue H, Derin RB, Guggino WB, Li M (September 2000). "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity". Cell. 103 (1): 169–79. doi:10.1016/s0092-8674(00)00096-9. PMID 11051556. S2CID 16697781.
  10. ^ Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (October 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784-91. doi:10.1152/ajprenal.00109.2003. PMID 12837682. S2CID 25450845.
  11. ^ Silver DL, Wang N, Vogel S (August 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. doi:10.1074/jbc.M304109200. PMID 12754212.
  12. ^ Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading


Categories