PFKFB4
Identifiers
Aliases	PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
External IDs	OMIM: 605320 MGI: 2687284 HomoloGene: 48288 GeneCards: PFKFB4
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,517,684 bp[1] End 48,562,015 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 108,820,846 bp[2] End 108,861,296 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte stromal cell of endometrium jejunal mucosa duodenum body of pancreas islet of Langerhans spleen ganglionic eminence bone marrow Top expressed in spermatocyte vastus lateralis muscle triceps brachii muscle knee joint jejunum duodenum skeletal muscle tissue tibialis anterior muscle esophagus temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding fructose-2,6-bisphosphate 2-phosphatase activity catalytic activity hydrolase activity ATP binding kinase activity 6-phosphofructo-2-kinase activity Cellular component cytosol Biological process fructose metabolic process metabolism fructose 2,6-bisphosphate metabolic process phosphorylation dephosphorylation carbohydrate phosphorylation positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5210 270198 Ensembl ENSG00000114268 ENSMUSG00000025648 UniProt Q16877 Q6DTY7 RefSeq (mRNA) NM_004567 NM_001317134 NM_001317135 NM_001317136 NM_001317137 NM_001317138 NM_001039215 NM_001039216 NM_001039217 NM_173019 RefSeq (protein) NP_001304063 NP_001304064 NP_001304065 NP_001304066 NP_001304067 NP_004558 NP_766607 Location (UCSC) Chr 3: 48.52 – 48.56 Mb Chr 9: 108.82 – 108.86 Mb PubMed search [3] [4]
Wikidata
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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 also known as PFKFB4 is an enzyme which in humans is encoded by the PFKFB4 gene.^[5][6]

Function

The bifunctional 6-phosphofructo-2-kinase (EC 2.7.1.105)/fructose-2,6-bisphosphatase (EC 3.1.3.46) (PFKFB) regulates the steady-state concentration of fructose 2,6-bisphosphate, an activator of a key regulatory enzyme of glycolysis, phosphofructokinase.

In 2012 research by scientists at Cancer Research UK’s London Research Institute show that an enzyme called PFKFB4 is essential for balancing these two processes – making sure the cell’s energy needs are met without allowing free radicals to build up and trigger cell death. Study leader Dr. Almut Schulze, said: “Our study suggests that PFKFB4 acts to fine-tune the process by which cells convert glucose into energy. Blocking this enzyme in prostate cancer cells grown in the lab stalled growth and triggered a catastrophic build-up of free-radicals, suggesting that it could be a suitable drug target. Importantly, this route to energy production is common to many different types of cancer, suggesting that drugs to target it could potentially be used to treat a variety of cancers.”^[7]