PIGF
Identifiers
Aliases	PIGF, phosphatidylinositol glycan anchor biosynthesis class F, OORS
External IDs	OMIM: 600153 MGI: 99462 HomoloGene: 31103 GeneCards: PIGF
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 46,580,937 bp[1] End 46,617,055 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E4|17 56.9 cM Start 87,304,684 bp[2] End 87,332,834 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte islet of Langerhans right adrenal gland rectum left adrenal gland monocyte stromal cell of endometrium body of pancreas Achilles tendon gallbladder Top expressed in spermatid secondary oocyte spermatocyte seminiferous tubule Paneth cell epithelium of stomach primitive streak yolk sac pyloric antrum condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ethanolaminephosphotransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5281 18701 Ensembl ENSG00000151665 ENSMUSG00000024145 UniProt Q07326 O09101 RefSeq (mRNA) NM_002643 NM_173074 NM_008838 RefSeq (protein) NP_002634 NP_775097 NP_032864 Location (UCSC) Chr 2: 46.58 – 46.62 Mb Chr 17: 87.3 – 87.33 Mb PubMed search [3] [4]
Wikidata
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Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.^[5][6][7]

Function

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.^[7]