PIGT
Identifiers
AliasesPIGT, MCAHS3, NDAP, PNH2, CGI-06, phosphatidylinositol glycan anchor biosynthesis class T
External IDsOMIM: 610272 MGI: 1926178 HomoloGene: 6134 GeneCards: PIGT
Orthologs
SpeciesHumanMouse
Entrez

51604

78928

Ensembl

ENSG00000124155

ENSMUSG00000017721

UniProt

Q969N2

Q8BXQ2

RefSeq (mRNA)

NM_001184728
NM_001184729
NM_001184730
NM_015937

NM_133779
NM_001362644
NM_001362645
NM_001378795

RefSeq (protein)

NP_001171657
NP_001171658
NP_001171659
NP_057021

NP_598540
NP_001349573
NP_001349574
NP_001365724
NP_001394210

Location (UCSC)Chr 20: 45.42 – 45.46 MbChr 2: 164.34 – 164.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.[5][6][7]

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[6]

Interactions

PIGT has been shown to interact with PIGK[8] and GPAA1.[7][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124155 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017721 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vainauskas S, Menon AK (Apr 2005). "Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex". J Biol Chem. 280 (16): 16402–9. doi:10.1074/jbc.M414253200. PMID 15713669.
  6. ^ a b "Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T".
  7. ^ a b Ohishi K, Inoue N, Kinoshita T (August 2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC 149153. PMID 11483512.
  8. ^ Ohishi, Kazuhito; Nagamune Kisaburo; Maeda Yusuke; Kinoshita Taroh (Apr 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. 278 (16): 13959–67. doi:10.1074/jbc.M300586200. ISSN 0021-9258. PMID 12582175.
  9. ^ Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (Aug 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 277 (34): 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837.

Further reading


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