PIK3C2G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WWE
Identifiers
Aliases	PIK3C2G, PI3K-C2-gamma, PI3K-C2GAMMA, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
External IDs	OMIM: 609001 MGI: 1203730 HomoloGene: 3362 GeneCards: PIK3C2G
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.3 Start 18,242,961 bp[1] End 18,648,416 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G2|6 69.7 cM Start 139,564,219 bp[2] End 139,915,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis hair follicle skin of abdomen right lobe of liver gallbladder stomach body of stomach seminal vesicula pylorus vulva Top expressed in stomach epithelium of stomach morula outer nuclear layer proximal tubule spermatid liver lip cumulus cell inner nuclear layer More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding transferase activity kinase activity phosphatidylinositol phosphate kinase activity phosphatidylinositol binding 1-phosphatidylinositol-3-kinase activity ATP binding 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol 3-kinase activity Cellular component cytosol membrane plasma membrane phosphatidylinositol 3-kinase complex cytoplasm Biological process phosphatidylinositol-mediated signaling phosphatidylinositol phosphate biosynthetic process chemotaxis phosphorylation phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol 3-kinase signaling cell migration phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5288 18705 Ensembl ENSG00000139144 ENSMUSG00000030228 UniProt O75747 O70167 RefSeq (mRNA) NM_001288772 NM_001288774 NM_004570 NM_011084 NM_207683 RefSeq (protein) NP_001275701 NP_001275703 NP_004561 NP_035214 NP_997566 Location (UCSC) Chr 12: 18.24 – 18.65 Mb Chr 6: 139.56 – 139.92 Mb PubMed search [3] [4]
Wikidata
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Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.^[5][6]

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.^[6]